0000000000470062
AUTHOR
Vannina Elena González Marrachelli
showing 3 related works from this author
Different role of endothelin ETA and ETB receptors and endothelial modulators in diabetes-induced hyperreactivity of the rabbit carotid artery to end…
2004
The influence of diabetes on regulatory mechanisms and specific receptors implicated in the contractile response of isolated rabbit carotid arteries to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was greater in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or NG-nitro-L-arginine enhanced contractions in response to endothelin-1 only in control arteries, without modifying the endothelin-1 response in diabetic arteries. Indomethacin, furegrelate (thromboxane A2 inhibitor), or cyclo-(D-Asp-Pro-D-Val-Leu-D-Trp) (BQ-123; endothelin ETA receptor antagonist) inhibited the contractions in response to endothel…
Contribution of endothelin receptors and cyclooxygenase-derivatives to the altered response of the rabbit renal artery to endothelin-1 in diabetes
2006
The influence of diabetes on regulatory mechanisms and specific receptors implicated in the response of isolated rabbit renal artery to endothelin-1 was examined. Endothelin-1 induced a concentration-dependent contraction that was less potent in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal or NG-nitro-L-arginine (L-NOARG) enhanced contractions to endothelin-1 either in control and diabetic arteries. Indomethacin inhibited endothelin-1-induced response in control arteries, but enhanced it in diabetic arteries. In contrast to that observed in rubbed and in L-NOARG treated arteries, in the presence of indomethacin the contractile action of endotheli…
Influencia de la diabetes experimental sobre la reactividad de las arterias basilar, carótida y renal de conejo a la endotelina-1
2006
RESUMEN Las complicaciones vasculares de la diabetes son principal causa de morbi-mortalidad del paciente diabético. Se ha estudiado la influencia de la diabetes experimental sobre la reactividad de las arterias basilar, carótida y renal a la endotelina-1 utilizando un modelo que permite el registro de la tensión isométrica desarrollada por los diferentes segmentos arteriales. Las conclusiones obtenidas han sido: 1. La diabetes experimental modifica la respuesta vascular a la endotelina-1 de forma dependiente del lecho vascular estudiado. 2. La diabetes induce hiperrreactividad de la arteria basilar de conejo a la endotelina-1 a través de al menos tres mecanismos: (1) menor modulación inhib…