Author: Cong-dat Pham

0000000000471514

AUTHOR

Cong-dat Pham

0000-0002-0747-4343

showing 1 related works from this author

Aaptamine Derivatives from the Indonesian Sponge Aaptos suberitoides

2013

Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.

PharmacologyMolecular StructurebiologyMurine lymphomaStereochemistryOrganic ChemistryPharmaceutical ScienceAntineoplastic AgentsAaptos suberitoidesbiology.organism_classificationPoriferaAnalytical ChemistryInhibitory Concentration 50MiceSpongeComplementary and alternative medicineIndonesiaDrug DiscoveryAnimalsHumansMolecular MedicineInhibitory concentration 50Drug Screening Assays AntitumorNaphthyridinesNuclear Magnetic Resonance BiomolecularJournal of Natural Products

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