Aaptamine Derivatives from the Indonesian Sponge Aaptos suberitoides

6533b820fe1ef96bd127a4b4

RESEARCH PRODUCT

Aaptamine Derivatives from the Indonesian Sponge Aaptos suberitoides

Peter Proksch Cong-dat Pham Daowan Lai Werner E.g. Müller Nicole J. De Voogd Rudolf Hartmann

subject

Pharmacology Molecular Structure biology Murine lymphoma Stereochemistry Organic Chemistry Pharmaceutical Science Antineoplastic Agents Aaptos suberitoides biology.organism_classification Porifera Analytical Chemistry Inhibitory Concentration 50 Mice Sponge Complementary and alternative medicine Indonesia Drug Discovery Animals Humans Molecular Medicine Inhibitory concentration 50 Drug Screening Assays Antitumor Naphthyridines Nuclear Magnetic Resonance Biomolecular

description

Four new aaptamine derivatives (1-4) along with aaptamine (5) and three related compounds (6-8) were isolated from the ethanol extract of the sponge Aaptos suberitoides collected in Indonesia. The structures of the new compounds were unambiguously determined by one- and two-dimensional NMR and by HRESIMS measurements. Compounds 3, 5, and 6 showed cytotoxic activity against the murine lymphoma L5178Y cell line, with IC(50) values ranging from 0.9 to 8.3 μM.

year	journal	country	edition	language
2013-01-02	Journal of Natural Products

https://doi.org/10.1021/np300794b

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