0000000000471589

AUTHOR

Katja Hilbert

showing 3 related works from this author

Containment of a Large SARS-CoV-2 Outbreak Among Healthcare Workers in a Pediatric Intensive Care Unit.

2020

Objective Healthcare workers (HCWs) are particularly exposed SARS-CoV-2 because they are critical in preventing viral transmission and treating COVID-19 patients. Within HCWs, personnel of intensive care units (ICUs) are at the forefront of treating patients with a severe course of COVID-19 infection and therefore represent an extremely vulnerable group. Thus, our objective is to contribute to establish means of infection control protecting HCWs in the frontline of the current pandemic. Design An outbreak of SARS-CoV-2 was detected and contained in a pediatric ICU (PICU). The first positive case was identified with a point-of-care diagnostic system on site. Real-time PCR-based testing syste…

Microbiology (medical)AdultMalemedicine.medical_specialtyInfectious Disease Transmission Patient-to-ProfessionalSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Health PersonnelPneumonia ViralPsychological interventionIntensive Care Units PediatricHospitals UniversityTertiary Care Centers03 medical and health sciencesBetacoronavirusYoung Adult0302 clinical medicine030225 pediatricsIntensive careGermanyPandemicHealth caremedicineInfection controlHumansPediatrics Perinatology and Child Health030212 general & internal medicinePandemicsPediatric intensive care unitInfection Controlbusiness.industrySARS-CoV-2virus diseasesOutbreakCOVID-19Middle AgedInfectious DiseasesPediatrics Perinatology and Child HealthEmergency medicineQuarantineFemalebusinessCoronavirus InfectionsThe Pediatric infectious disease journal
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Selection of a precore mutant after vertical transmission of different hepatitis B virus variants is correlated with fulminant hepatitis in infants

1995

The incidence of perinatal transmission of hepatitis B virus (HBV) depends on the HBeAg/anti-HBe status of the mother. While children of HBeAg-positive mothers have a 90% probability of acquiring a chronic hepatitis B virus carrier state, babies of anti-HBe-positive mothers are more likely to develop fulminant hepatitis within the first 3 to 4 months of life. There is evidence that precore (pre-C) mutations of the HBV can be associated with fulminant hepatitis. The pre-C region was therefore examined in sera from nine infants with fulminant hepatitis after vertical transmission, one HBeAg-positive and seven anti-HBe-positive mothers by polymerase chain reaction (PCR) and direct sequence ana…

AdultHepatitis B virusAdolescentMolecular Sequence DataPopulationmedicine.disease_causeVirusPregnancyVirologymedicineHumansHepatitis B e AntigensFulminant hepatitiseducationHepatitis B viruseducation.field_of_studyBase Sequencebiologyvirus diseasesHepatitis BHepatitis Bmedicine.diseasebiology.organism_classificationVirologyInfectious Disease Transmission Verticaldigestive system diseasesInfectious DiseasesHepadnaviridaeHBeAgDNA ViralMutationImmunologyFemaleViral diseaseSequence AnalysisJournal of Medical Virology
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A novel mutation in FGFR-3 disrupts a putative N-glycosylation site and results in hypochondroplasia

2000

Winterpacht, Andreas, Katja Hilbert, Christiane Stelzer, Thorsten Schweikardt, Heinz Decker, Hugo Segerer, Jürgen Spranger, and Bernhard Zabel. A novel mutation in FGFR-3 disrupts a putative N-glycosylation site and results in hypochondroplasia. Physiol. Genomics 2: 9–12, 2000.—Fibroblast growth factor receptor 3 (FGFR3) is a glycoprotein that belongs to the family of tyrosine kinase receptors. Specific mutations in the FGFR3 gene are associated with autosomal dominant human skeletal disorders such as hypochondroplasia, achondroplasia, and thanatophoric dysplasia. Hypochondroplasia (HCH), the mildest form of this group of short-limbed dwarfism disorders, results in ∼60% of cases from a mut…

GlycosylationGlycosylationPhysiologyDNA Mutational AnalysisHypochondroplasiaOsteochondrodysplasiasReceptor tyrosine kinaseMicechemistry.chemical_compoundGeneticsmedicineAnimalsHumansPoint MutationReceptor Fibroblast Growth Factor Type 3N-Glycosylation SiteGeneticschemistry.chemical_classificationBinding SitesBase SequencebiologyInfantDNAProtein-Tyrosine Kinasesmedicine.diseaseReceptors Fibroblast Growth FactorMolecular biologyProtein Structure TertiaryMice Inbred C57BLAmino Acid SubstitutionchemistryFibroblast growth factor receptorMutationbiology.proteinFemaleGlycoproteinNovel mutationPhysiological Genomics
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