ATEROSCLEROSI CAROTIDEA E PERIFERICA E RESTENOSI CORONARICA DOPO ANGIOPLASTICA PERCUTANEA.

Infection and inflammation influence the outcome of patient with asymptomatic carotid lesions

BACKGROUND AND PURPOSE: It is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. METHODS: We studied 668 subjects divided in 3 groups according to the results of carotid ultrasound examination: (1) normal subjects, if intima-media thickness (IMT) was 1.5 mm. Traditional cardiovascular risk factors were investigated, and laboratory analysis included measurement of plasma lipids, fibrinogen, C-reactive protein, IgG antibodies for helicobacter pylori (HP), cy…

Preclinical carotid atherosclerosis enhances the global cardiovascular risk and increases the rate of cerebro- and cardiovascular events in a five-year follow-up

AIM: To evaluate if the intima-media thickening (IMT) and asymptomatic carotid plaque (ACP), as expression of carotid preclinical atherosclerosis (pre-ATS), can provide further information on the global cardiovascular risk (GCVR). METHODS: We studied 454 asymptomatic subjects, with a cluster of risk factors (RF), and evaluated the incidence of a first cardiovascular (CV) event in a five-year follow-up. The subjects at admission were subdivided in three groups of risk. RESULTS: Events occurred in 38% of subjects at high risk, in 13% and 6% of subjects at intermediate and low risk (p<0.003). Among evaluated parameters, carotid pre-ATS was a predictive marker of CV events (OR 2.7, 95% IC 1.4-5…

MULTIFOCAL ATHEROSCLEROSIS INFLUENCING THE OUTCOME OF PATIENTS WITH ACUTE AND CHRONIC CORONARY HEART DISEASE

MULTIFOCAL ATHEROSCLEROSIS INFLUENCING THE OUTCOME OF PATIENTS WITH ACUTE AND CHRONIC CORONARY HEART DISEASE

Older age and markers of inflammation are strong predictors of clinical events in women with asymptomatic carotid lesions.

PREDICTION OF CEREBROVASCULAR AND CARDIOVASCULAR EVENTS IN PATIENTS WITH SUBLINICAL CAROTID ATHEROSCLEROSIS: THE ROLE OF C-REACTIVE PROTEIN

Background Several studies have suggested that inflammation and infection may be important for accelerated progression of atherosclerosis, but few data are available on subjects with early stages of atherosclerosis. Methods and Results We included, in a prospective 5-year follow-up study, 150 patients with subclinical carotid atherosclerosis, evaluating at baseline all established traditional cardiovascular risk factors (eg, older age, male sex, obesity, hypertension, diabetes, smoking, family history of coronary artery disease, and dyslipidemia); 2 markers of inflammation, fibrinogen, and high-sensitivity C-reactive protein (CRP); and the seropositivity to Helicobacter pylori, Chlamydia pn…

RISK FACTORS, MULTIFOCAL ATHEROSCLEROSIS AND RESTENOSIS POST-PTCA

Relationship between endothelial dysfunction, intima media thickness, hypertension and other cardiovascular risk factors in asymptomatic subjects

Infection and inflammation influence the outcome of patients with asymptomatic carotid lesions. Int Angiol. 2004. 23(suppl.1)

Asymptomatic carotid lesions add to cardiovascular risk prediction.

AIM To show that subclinical atherosclerosis (subclinical-ATS) of carotid arteries [intima-media thickness (IMT) or asymptomatic carotid plaque (ACP)], may provide additional information for risk stratification, in asymptomatic patients, aged greater than 45 years, with a cluster of risk factors (RFs). METHODS AND RESULTS We studied 558 asymptomatic patients (235 males). RFs for atherosclerosis were assessed and the 10-year-risk was calculated according to the Italian risk score. Doppler ultrasound of carotid arteries identified the presence of IMT greater than 0.9 mm in 183 patients and ACP in 147 patients. One hundred and fifty-three patients developed cerebrovascular or cardiovascular (C…

ATHEROSCLEROSIS AND MARKERS OF INFLAMMATION IN PATIENTS WITH METABOLIC SYNDROME

Livelli plasmatici di fibrinogeno in soggetti con infarto miocardico acuto: relazione con gli eventi nel follow-up a 42 mesi

L’eta’ e gli elevati livelli di proteina C-reattiva e fibrinogeno sono forti predittori di eventi clinici in una popolazione di donne con aterosclerosi carotidea.

INFLUENCE OF CAROTID AND PERIPHERAL ATHEROSCLEROSIS ON THE OUTCOME OF PATIENTS WITH ACUTE CORONARY SYNDROME

Markers of Inflammation and Infection Influence the Outcome of Patients With Baseline Asymptomatic Carotid Lesions

Background and Purpose— It is still in debate whether the evaluation of markers of infection and inflammation may be of importance for cerebrovascular and cardiovascular prevention, and we aimed to investigate this field in a prospective 5-year clinical follow-up study in patients with early stages of atherosclerosis. Methods— We studied 668 subjects divided in 3 groups according to the results of carotid ultrasound examination: (1) normal subjects, if intima-media thickness (IMT) was &lt;0.9 mm; (2) with IMT, if IMT was between 0.9 and 1.5 mm; and (3) with asymptomatic carotid plaque, if IMT was &gt;1.5 mm. Traditional cardiovascular risk factors were investigated, and laboratory analysis…

CAROTID INTMAL-MEDIAL THICKNESS ANS ENDOTHELIAL FUNCTION IN YOUNG ADULTS PATIENTS WITH MYOCARDIAL INFARCTION

Infection and inflammation influence the outcome of patients with asymptomatic carotid lesions

Preclinical atherosclerosis and metabolic syndrome increase cardio- and cerebrovascular events rate: a 20-year follow up

BACKGROUND: Intima-media thickness (IMT) is a validated marker of preclinical atherosclerosis and a predictor of cardiovascular events. PATIENTS: We studied a population of 529 asymptomatic patients (age 62 ± 12.8 years), divided into two groups of subjects with and without Metabolic Syndrome (MetS). METHODS: All patients, at baseline, have had a carotid ultrasound evaluation and classified in two subgroups: the first one without atherosclerotic lesions and the second one with preclinical atherosclerosis (increased IMT or asymptomatic carotid plaque). Cardiovascular endpoints were investigated in a 20-years follow-up. RESULTS: There were 242 cardiovascular events: 144 among patients with Me…

Asymptomatic carotid lesions and aging: role of hypertension and other traditional and emerging risk factors

ASYMPTOMATIC CAROTID LESIONS AND AGING: ROLE OF HYPERTENSION AND OTHER TRADITIONAL AND EMERGING RISK FACTORS BACKGROUND: We evaluated the prevalence of intima-media thickening (IMT) and asymptomatic carotid plaque (ACP) in a group of subjects with or without traditional and/or emerging risk factors (RF). METHODS: There were 631 subjects (313 male and 318 female) aged between 19 and 97 years, asymptomatic for cerebro- and cardiovascular diseases. The following measurements were used: anamnesis, physical examination, height and sitting blood pressure. Biochemistry variables were also considered: total cholesterol, HDL-C, LDL-C, triglycerides, fibrinogen, high sensitive C-reactive protein, IgG…

MULTIFOCAL ATHEROSCLEROSIS INFLUENCE THE OUTCOME OF PATIENTS UNDERWENT TO PRIMARY PTCA

Association of elevated fibrinogen and C-reactive protein levels with carotid lesions in patients with newly diagnosed hypertension or type II diabetes.

BACKGROUND: Inflammation may be important for accelerated progression of atherosclerosis in patients with hypertension or diabetes, but few studies included subjects with early stages of atherosclerosis such as those with asymptomatic carotid lesions. METHODS: We studied 100 patients with newly diagnosed hypertension and another 100 patients with newly diagnosed type II diabetes to evaluate in such groups the association of two markers of inflammation, fibrinogen and C-reactive protein (CRP), with carotid atherosclerosis, beyond traditional cardiovascular risk factors (e.g., older age, male gender, obesity, smoking, family history of CAD, dyslipidemia). RESULTS: We found positive correlatio…

Markers of inflammation are strong predictors of subclinical and clinical atherosclerosis in women with hypertension

Cardiovascular diseases in women still rises and remains their leading cause of death in most developed countries; yet we have less sex-specific data in women than in men as a result of lower enrollment in clinical trials and low rates of sex-specific reporting. The aim of our study was to evaluate in hypertensive postmenopausal women the potential predictive role of markers of inflammation, for example, fibrinogen and C-reactive protein (CRP), on subclinical and clinical atherosclerosis, beyond that of the other established cardiovascular risk factors. We studied 127 asymptomatic hypertensive postmenopausal women with different degrees of carotid intima–media thickness, as examined by the …

MULTIFOCAL ATHEROSCLEROSIS INFLUENCE THE UTCOME OF PATIENTS UNDERWENT TO PRIMARY PTCA

PREVALENZA DELLE LESIONI CAROTIDEE IN UNA POPOLAZIONE MEDITERRANEA DI IPERTESI

Peripheral atherosclerosis is associated with the occurrence of restenosis after percutaneous coronary intervention

INTRODUCTION: The aim of our study was to evaluate, in patients with proven coronary artery disease (CAD) and treated with elective percutaneous coronary intervention (PCI), whether the coexistence of asymptomatic carotid and femoral atherosclerotic lesions would provide prognostic information in terms of occurrence of restenosis. METHODS: We studied 104 patients with CAD (M/F=77/27), mean age 60.5+/-9 years. All patients were treated with elective PCI. After PCI the suspicion of restenosis was confirmed by coronary angiography. All patients underwent ultrasound duplex scan of carotid and femoral-popliteal-tibial axis to detect atherosclerotic lesions. According to ultrasound results, patie…

INFLUENCE OF CAROTID AND PERIPHERAL ATHERLSCLEROSIS IN THE OUTCOME OF PATIENTS WITH ACUTE CORONARY SYNDROME

INFLUENCE OF CAROTID AND PERIPHERAL ATHERLSCLEROSIS IN THE OUTCOME OF PATIENTS WITH ACUTE CORONARY SYNDROME

CAROTID AND PERIPHERAL ATHEROSCLEROSIS IN PATIENTS UNDERWENT TO PRIMARY PCI AND OUTCOME ASSOCIATED WITH MULTIFOCAL ATHEROSCLEROSIS

INFLUENZA DELL’ATEROSCLEROSI MULTIFOCALE NELL’OUTCOME DI PAZIENTI CHE HANNO EFFETTUATO PTCA PRIMARIA

Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24-month follow-up study

Background The purpose of this study was to investigate whether the vasodilator response to brachial artery and the presence of carotid lesions may have a prognostic significance in patients with early stages of atherosclerosis. Methods and results Vascular echography was performed to analyze flow-mediated vasodilatation (FMD) at the brachial artery and intima–media thickness (IMT) of carotid arteries in 84 asymptomatic patients. At baseline, we evaluated all the established traditional cardiovascular risk factors. Transient ischemic attack, stroke, effort or unstable angina, acute myocardial infarction, peripheral arterial disease and cerebrovascular and cardiovascular death served as outc…

RUOLO DEI FATTORI DI RISCHIO TRADIZIONALI E DELLA PROTEINA-C REATTIVA NELLA PATOGENESI DELLA DISFUNZIONE ENDOTELIALE

Prediction of vascular events in subjects with subclinical atherosclerosis and the metabolic syndrome: the role of markers of inflammation.

Disfunzione endoteliale e malattia carotidea in pazienti con bright liver echopattern

RISK FACTORS AND MULTIFOCAL ATHEROSCLEROSIS INFLUENCE THE RATE OF RESTENOSIS POST-PTCA

The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis.

Recent guidelines published by the joint European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but little data is available on the role of CRP in patients with carotid lesions. We studied in 472 subjects, 236 with and 236 without hypertension, gender- and age-matched, with and without early stages of atherosclerosis (e.g. those with asymptomatic intima-media thickness >0.9 mm), the influence of all the other traditional cardiovascular risk factors (e.g. older age, male gender, obesity, diabetes, smoking habit, family history of coronary artery diseas…

LESIONI CAROTIDEE ASINTOMATICHE, INCIDENZA DI EVENTI VASCOLARI FATALI E NON IN UNA POPOLAZIONE DI DIABETICI DI TIPO II: RUOLO DELLA PROTEINA C REATTIVA AD ALTA SENSIBILITA’

ATRIAL FIBRILLATION AND MILD COGNITIVE IMPAIRMENT: WHAT CORRELATION?

ATRIAL FIBRILLATION AND MILD COGNITIVE IMPAIRMENT: WHAT CORRELATION? Aim. Atrial fibrillation (AF), in addition to macroembolic complications, may also produce multiple cerebral ischemic areas due to microembolic phenomena and transient hypoperfusion, eventually leading to a progressive cognitive impairment and even to acclaimed vascular dementia. The aim of this study was to evaluate the prevalence of cognitive impairment in patients with AF. The reported results concern data obtained at the moment of recruitment. Methods. The authors studied 42 patients with a history of non valvular AF (paroxysmal, persistent, recurrent or permanent) and 40 homogenous controls in sinus rhythm without pre…

CORRELAZIONE TRA ATEROSCLEROSI EPERIFERICA E CORONARICA IN PAZIENTI CON CARDIOPATIA ISCHEMICA CRONICA

PERIPHERAL ATEROSCLEROSIS AND RESTENOSIS AFTER PCI

ASSOCIAZIONE TRA ATEROSCLEROSI CAROTIDEA, DISFUNZIONE ENDOTELIALE E STEATOSI EPATICA IN UNA POPOLAZIONE CON SINDROME METABOLICA.

NON INVASIVE VALUATION OF ENDOTHELIAL FUNCTION IN THE PATIENTS WITH ANDERSON- FABRY DISEASE

FIBRILLAZIONE ATRIALE E MILD COGNITIVE IMPAIRMENT: QUALE RELAZIONE.

Aspetti emoreologici nella iperviscosità policitemica e sierica

I fattori strutturali in grado di modificare la viscosità ematica sono la massa cellulare, le frazioni proteiche plasmatiche e la deformabilità del globulo rosso. In base alla presenza di uno di questi fattori si distinguono le diverse condizioni primarie di iperviscosità. Mentre l'iperviscosità policitemica è possibile riscontrarla in molti quadri clinici caratterizzati dall'aumento della massa cellulare (policitemia vera, eritrocitosi, leucocitosi iperleucocitiche, trombocitemia), l'iperviscosità sierica è probabile evidenziarla in quadri clinici diversi quali mieloma, malattia di Waldenstrom, crioglobulinemia, disfibrinogenemie, malattie del connettivo, e l'iperviscosità sclerocitemica è…

Residual vein thrombosis and onset of post-thrombotic syndrome: Influence of the 4G/5G polymorphism of plasminogen activator inhibitor-1 gene

Abstract Background Plasminogen activator inhibitor-1 (PAI-1) is the most important inhibitor of plasminogen activator. The functional 4G/5G polymorphism of the gene coding for PAI-1 may affect PAI-1 plasmatic activity, influencing the imbalance between coagulation and fibrinolysis cascades. In this prospective cohort analytic study, we investigated the role of this single nucleotide polymorphism in the persistence of thrombotic lesion and the occurrence of post-thrombotic syndrome. Patients/Methods In a group of 168 patients with post-surgical deep vein thrombosis of the legs, we analyzed the 4G/5G polymorphism in the promoter of PAI-1 gene and plasmatic PAI-1 activity. Enrolled patients w…

Ulcere venose: rilievi riguardanti sia aspetti reologici e funzionali dei polimorfonucleati che le concentrazioni plasmatiche delle gelatinasi e dei loro inibitori

PREVALENCE OF CAROTID LESIONS IN A MEDITERRANEAN POPULTION OF HYPERTENSIVES

STATINE E ARTERIOPATIA PERIFERICA: NECESSITA’ DI UN APPROCCIO VASCOLARE GLOBALE.

INIBITORI DEL SISTEMA RENINA-ANGIOTENSINA E FIBRILLAZIONE ATRIALE: UNO STUDIO RETROSPETTIVO SU 187 PAZIENTI

INFLUENZA DELL’ATEROSCLEROSI CAROTIDEA PRECLINICA SUGLI EVENTI CEREBRO- E CARDIOVASCOLARI IN 5 ANNI DI FOLLOW-UP. INFLUENCE OF PRECLINICAL CAROTID ATHEROSCLEROSIS ON CEREBRO- AND CARDIOVASCULAR EVENTS IN A FIVE YEARS FOLLOW-UP

Introduzione: numerosi studi hanno utilizzato la valutazione dello spessore intima-media carotideo (IMT) come marker di aterosclerosi (ATS) preclinica ed è stato ampiamente dimostrato che l’IMT correla con la presenza di ATS coronarica ed è predittivo di eventi sia cardio- che cerebrovascolari. Scopo dello studio: valutare se in soggetti asintomatici la presenza di ATS carotidea preclinica, ispessimento medio intimale carotideo (IMT) e placca carotidea asintomatica (PCA), aggiunga ulteriori informazioni nella stratificazione del rischio permettendo di individuare soggetti che potrebbero beneficiare di un trattamento più aggressivo, anche farmacologico, dei fattori di rischio presenti. Mater…

PREVALENCE OF CAROTID LESIONS ACCORDING TO TRADITIONAL RISK FACTORS IN A POPULATION ASYMPTOMATIC FOR CARDIOVASCULAR DISEASE

LA CHLAMYDIA PNEUMONIAE E’ CORRELABILE CON LA ROTTURA DELLA PLACCA ATEROSCLEROTICA?

Asymptomatic Carotid Lesions and Aging: Role of Hypertension and Other Traditional and Emerging Risk Factors

Background We evaluated the prevalence of intima-media thickening (IMT) and asymptomatic carotid plaque (ACP) in a group of subjects with or without traditional and/or emerging risk factors (RF). Methods There were 631 subjects (313 male and 318 female) aged between 19 and 97 years, asymptomatic for cerebro- and cardiovascular diseases. The following measurements were used: anamnesis, physical examination, height and sitting blood pressure. Biochemistry variables were also considered: total cholesterol, HDL-C, LDL-C, triglycerides, fibrinogen, high sensitive C-reactive protein, IgG antibodies for Helicobacter pylori (HP), cytotoxic HP, cytomegalovirus and Chlamydia pneumoniae . Finally, an …

Prediction of cardio- and cerebro-vascular events in patients with subclinical carotid atherosclerosis and the metabolic syndrome.

Alteraziioni morfofunzionali vascolari in una popolazione con sindrome metabolica e steatosi epatica ecografica

PREVALENCE OF A MILD COGNITIVE IMPAIRMENT IN PATIENTS WITH ATRIAL FIBRILLATION

Prediction of cardio- and cerebro-vascular events in patients with subclinical carotid atherosclerosis and low HDL-cholesterol.

Low HDL-cholesterol concentrations are associated with increased cardiovascular risk and recent evidences suggest that HDL may aggravate the atherosclerotic process promoting inflammation: HDL are anti-inflammatory in the absence of inflammation but can become proinflammatory in the presence of atherosclerosis. Yet, no data is available on the cardiovascular outcome in subjects with low HDL-cholesterol and early stages of atherosclerosis. Therefore, we included in a prospective 5-year follow-up study 150 subjects with low HDL-cholesterol concentrations and subclinical carotid atherosclerosis, as assessed by carotid colour doppler, evaluating at baseline all the established traditional cardi…

ELEVATED C-REACTIVE PROTEIN LEVELS ARE A STRONG PREDICTOR OF CLINICAL EVENTS IN HYPERTENSIVE PATIENTS WITH EARLY STAGE OF ATHEROSCLEROSIS

PROGNOSTIC IMPACT OF HYPERTENSION AND CAROTIID LESIONS N A FIVE YEARS FOLLOW UP

Older age and markers of inflammation are strong predictors of clinical events in women with asymptomatic carotid lesions

OBJECTIVE: Limited information exists regarding the association between markers of inflammation, such as high-sensitivity C-reactive protein (hs-CRP) and fibrinogen, and adverse events in postmenopausal women with subclinical atherosclerosis. Therefore, we investigated the prognostic impact of traditional risk factors and inflammation on adverse cardiac events in women with asymptomatic carotid lesions. DESIGN: We studied 250 postmenopausal women who were free of cardiovascular disease. Traditional cardiovascular risk factors were investigated, and laboratory analysis included measurement of plasma lipids, fibrinogen, and hs-CRP. The early phases of carotid atherosclerosis were assessed by …

Endothelial dysfunction and carotid lesions are strong predictors of clinical events in patients with early stages of atherosclerosis: a 24 months follow-up study.

EXTRACORONARY ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

Markers of inflammation are strong predictors of subclinical and clinical atherosclerosis in women with hypertension

DANNO VASCOLARE E TERAPIA

INCIDENZA DELL’ATEROSCLEROSI CORONARICA E PERIFERICA IN RELAZIONE ALLA PRESENZA DELLA SINDROME METABOLICA IN UNA POPOLAZIONE AMBULATORIALE NON SELEZIONATA: RUOLO DELLA PCR E DEL FIBRINOGENO

ASSOCIATION OF ELEVATED FIBRINOGEN AND C-REACTIVE PROTEIN LEVELS WITH CAROTID LESIONS IN PATIENTS WITH EARLY ONSET OF HYPERTENSION OR TYPE-II DIABETES

L’eta’ e gli elevati livelli di proteina C-reattiva e fibrinogeno sono forti predittori di eventi clinici in una popolazione di donne con aterosclerosi carotidea.

ELEVATED C-REATIVE PROTEIN LEVELS ARE STRONG PREDICTOR OF CLINICAL EVENTS IN HYPERTENSIVE PATIENTS WITH EARLY STAGES OF ATHEROSCLEROSIS

Impact of preclinical carotid atherosclerosis on global cardiovascular risk stratification and events in a 10-year follow-up: comparison between the algorithms of the Framingham Heart Study, the European SCORE and the Italian 'Progetto Cuore'

Background The aim of the study was to compare three widely used algorithms for stratification of the global cardiovascular risk (GCVR): the Framingham Heart Study (FHS) score, the European systemic coronary risk estimation (SCORE) and the Italian 'Progetto Cuore' (heart project) score. It was also investigated how preclinical carotid atherosclerosis (pre-ATS) might influence the incidence and improve the risk prediction of cerebrovascular and cardiovascular events. Methods Subjects (n = 358) without previous history of cardiovascular disease (CVD) were recruited and the GCVR was calculated for each patient. An ultrasound evaluation of the carotid arteries was also performed. Results Accord…

LA PROTEINA C REATTIVA ED IL FIBRINOGENO NELLA VALUTAZIONE DEL RISCHIO REALE DI EVENTI VASCOLARI IN PAZIENTI CON DIABETE MELLITO TIPO II.

Behaviour of the plasma concentration of gelatinases and their tissue inhibitors in subjects with venous leg ulcers.

Venous leg ulcers are common in subjects with chronic venous insufficiency. The increased intraluminal pressure causes alteration of the skin microcirculation, leukocyte activation and release of proteolytic enzymes leading to ulceration. An impaired expression and activity of matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs) might influence extracellular matrix degradation and deposition in chronic venous ulcers with the failure of the healing process. Our aim was to evaluate plasma concentration of gelatinases (MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in subjects with venous leg ulcers before and after the compression therapy. We enrolled 36 subjects (12 …

LA PRESENZA DI ELEVATI LIVELLI DI FIBRINOGENO E PROTEINA C-REATTIVA SONO SIGNIFICATIVAMENTE ASSOCIATI ALLA PRESENZA DI ATEROSCLEROSI CAROTIDEA NEI PAZIENTI IPERTESI O DIABETICI.

RELATIONSHIP BETWEEN PERIPHERAL AND CORONARY ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC ISCHEMIC HEART DISEASE

Disfunzione endoteliale e malattia carotidea in pazienti con bright liver echopattern

Increased levels of C-reactive protein and fibrinogen influence the risk of vascular events in patients with NIDDM

AIM: To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS: We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events…

CAROTID ATHEROSCLEROTIC LESIONS AS INDICATOR OF SYSTEMIC ATHEROSCLEROSIS

VALUTAZIONE NON INVASIVA DELLA FUNZIONE ENDOTELIALE IN PAZIENTI AFFETTI DALLA MALATTIA DI ANDERSON-FABRY

Women and peripheral arterial disease: same disease, different issues

Objectives Atherosclerosis is a multifactorial disease and, thus, its clinical manifestations are likely to present gender-specific differences with respect to their development, course, symptom complexes and prognosis. The present study aimed to examine sex differences in peripheral arterial disease (PAD) and its clinical correlates. Methods PAD severity, quality of life (assessed by ST-22), cardiovascular risk factors, inflammatory profile and comorbidity were assessed in 163 men and 68 women who were consecutively diagnosed with PAD at three Italian University vascular centres. Results Compared to men, women showed a higher prevalence of critical limb ischemia (P = 0.018), but had a less…

RUOLO DEI FATTORI DI RISCHIO TRADIZIONALI E DELLA PROTEINA-C REATTIVA NELLA PATOGENESI DELLA DISFUNZIONE ENDOTELIALE

PREVALENCE OF INTIMAL MEDIA THICKNESS AND PLAQUE IN CAROTID ARTERIES ACCORDING TO TRADITIONAL CARDIOVASCULAR RISK FACTORS IN A MEDITERRANEAN POPULATION ASYMPTOMATIC FOR CARDIOVASCULAR DISEASE

Prognostic impact of hypertension and carotid lesions in a five years follow-up

Significato clinico e prognostico dell'aterosclerosi carotidea nella valutazione del rischio cardiovascolare globale

TRIAL FIBRILLATION AND COGNITIVE IMPAIRMENT

DO MARKERS OF PRECLINICAL ATHEROSCLEROSIS INFLUENCE GLOBAL CARDIOVASCULAR RISK?

DO MARKERS OF PRECLINICAL ATHEROSCLEROSIS INFLUENCE GLOBAL CARDIOVASCULAR RISK?