6533b82bfe1ef96bd128d90e
RESEARCH PRODUCT
The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis.
Giangennaro CoppolaGiuseppina NovoAlessandro MezzaniEgle CorradoSalvatore NovoManfredi RizzoIda Maria Muratorisubject
Malemedicine.medical_specialtySettore MED/09 - Medicina InternaInflammationAsymptomaticCoronary artery diseasePredictive Value of TestsRisk FactorsInternal medicineDiabetes mellitusCRP Hypertension Subclinical Atherosclerosis atherosclerosisInternal MedicinemedicineHumansIn patientFamily historyAgedbiologybusiness.industryC-reactive proteinMiddle Agedmedicine.diseaseC-reactive protein hypertension inflammation event atherosclerosisAtherosclerosisObesitySettore MED/11 - Malattie Dell'Apparato CardiovascolareCerebrovascular DisordersC-Reactive ProteinCase-Control StudiesHypertensionCardiologybiology.proteinFemalemedicine.symptombusinessBiomarkersFollow-Up Studiesdescription
Recent guidelines published by the joint European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but little data is available on the role of CRP in patients with carotid lesions. We studied in 472 subjects, 236 with and 236 without hypertension, gender- and age-matched, with and without early stages of atherosclerosis (e.g. those with asymptomatic intima-media thickness >0.9 mm), the influence of all the other traditional cardiovascular risk factors (e.g. older age, male gender, obesity, diabetes, smoking habit, family history of coronary artery disease, dyslipidemia) and of high sensitivity-CRP levels on cerebro- and cardio-vascular events in a 5 years follow-up. At the end of follow up, patients with hypertension had more events than those without (25% vs. 17%, p 0.9 mm), the influence of all the other traditional cardiovascular risk factors (e.g. older age, male sex, obesity, diabetes, smoking habit, family history of coronary artery disease, dyslipidaemia) and of high-sensitivity CRP levels on cerebrovascular and cardiovascular events in a 5-year follow up. Results: At the end of follow up, patients with hypertension had more events than those without (25% vs 17%, P < 0.05). Proportional hazard analysis revealed in the group of patients without hypertension the presence of baseline carotid lesions (P = 0.02) as predictor of events. In patients with hypertension, the presence of baseline carotid lesions (P = 0.04) and elevated CRP levels (P = 0.02) predicted clinical events. Patients with hypertension also showed a significant relationship between clinical events and quintiles of CRP levels (P < 0.01). Conclusion: Beyond the utility of high-sensitivity CRP levels in the prediction of early and late stages of atherosclerosis and subsequently on its association with clinical events, the therapeutic implications of these results remain to be evaluated by further studies
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-08-01 | Internal medicine journal |