0000000000480941

AUTHOR

Bonsignore M. R.

showing 4 related works from this author

Metabolic Consequences of Obstructive Sleep Apnea

2022

The effects of OSA on metabolism are quite complex, and obesity, diabetes, nonalcoholic fatty liver disease and dyslipidemia often coexist with OSA, making it difficult to tease out the independent effects of OSA on metabolic variables. There is firm experimental evidence of a detrimental impact of OSA on adipose tissue dysfunction, with intermittent hypoxia, sympathetic hyperactivity, and oxidative stress as the most important intermediate mechanisms. Sleep fragmentation or deprivation may also contribute to the metabolic dysfunction of OSA. This work reviews the current knowledge on this topic, as well as the results of studies on the effects of CPAP treatment.

InflammationDiabetes mellitu...CholesterolFree fatty acidInsulin resistanceContinuous positive airway pressure (CPAP)Settore MED/10 - Malattie Dell'Apparato RespiratorioCardiovascular riskMetabolic syndromeNonalcoholic fatty liver disease (NAFLD)
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Clinical phenotypes and comorbidity in European sleep apnoea patients

2016

PubMed ID: 27701416

MalePulmonologyPhysiologyApneamedicine.medical_treatmentlcsh:MedicineComorbidityPolysomnographyCardiovascular MedicineMedicine (all); Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)THERAPYBody Mass Index0302 clinical medicineRisk FactorsPositive airway pressureMedicine and Health SciencesInsomniaMedicineProspective StudiesContinuous positive airway pressurelcsh:ScienceProspective cohort studyClinical NeurophysiologyAged 80 and overHypersomniaMultidisciplinarymedicine.diagnostic_testMedicine (all)Sleep apneaMiddle AgedDEPRESSIONPREVALENCEComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMSPhenotypeNeurologyPhysiological ParametersCardiovascular DiseasesCARDIOVASCULAR-DISEASEFemaleInformationSystems_MISCELLANEOUSmedicine.symptomEngineering sciences. TechnologyHypopneaINSOMNIA SYMPTOMSResearch ArticleAdultmedicine.medical_specialtyInsomniaSleep ApneaAdolescentPOSITIVE AIRWAY PRESSUREPolysomnographySettore MED/10 - Malattie Dell'Apparato RespiratorioWhite PeopleYoung Adult03 medical and health sciencesSleep Apnea SyndromesDAYTIMEstomatognathic systemComorbiditatDiagnostic MedicineInternal medicinemental disordersHumansCOMMONAgedHYPOPNEABiochemistry Genetics and Molecular Biology (all)HYPERTENSIONbusiness.industrylcsh:RBody WeightComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKSBiology and Life Sciencesta3121medicine.diseaseComorbidityDyssomniasrespiratory tract diseasesnervous system diseasesComputingMethodologies_PATTERNRECOGNITIONAgricultural and Biological Sciences (all)030228 respiratory systemPhysical therapylcsh:QSleep DisordersPhysiological ProcessesSleepbusiness030217 neurology & neurosurgeryFollow-Up Studies
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Continuing professional development: introducing the ERS International Certificate in Respiratory Sleep Medicine

2017

What is the greatest challenge in the delivery of quality care to respiratory disease patients? Is it lack of resources, avoidable harm to patients, or more complex disease presentation? Healthcare delivery has been in the media spotlight in recent months across many countries and the question of how to deliver safe, effective and efficient care to patients remains at the forefront of political agendas at a national level. Education is the passport to the future and the European Respiratory Society (ERS) is in the unique position of being able to work with the most respected respiratory experts internationally in order to design and deliver educational activities to raise standards of train…

Pulmonary and Respiratory Medicinemedicine.medical_specialty5educationRespiratory SystemCertificationSettore MED/10 - Malattie Dell'Apparato RespiratorioSleep medicine/dk/atira/pure/subjectarea/asjc/2700/274003 medical and health sciences0302 clinical medicinemedicine030212 general & internal medicinelcsh:RC705-779Medical educationScience & Technologybusiness.industryEditorialslcsh:Diseases of the respiratory systemCertificatehumanitiesEditorial030228 respiratory systemContinuing professional development18businessLife Sciences & BiomedicineEducation respiratory medicineBreathe
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Pathophysiology of Obstructive Sleep Apnea (OSA)

2021

Obstructive sleep apnea (OSA) is a complex disorder characterized by total or partial collapse of the upper airways (UA) during sleep, causing obstructive apneas or hypopneas, respectively. During respiratory events, respiratory efforts occur against the restricted or collapsed upper airway, hypoxia and hypercapnia develop, and sympathetic activation increases. The main symptoms of OSA are intermittent snoring and excessive daytime sleepiness. OSA is often associated with obesity, hypertension, and increased cardiovascular risk. Pathophysiological aspects include: anatomical and physiological determinants of UA closure, and immediate and long-term consequences of chronic intermittent hypoxi…

sympathetic nervous systemobesityintermittent hypoxiaSettore MED/10 - Malattie Dell'Apparato Respiratorio
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