Lactate Dehydrogenase Isozymes in the Developing Rat Brain

1962

THE immaturity and the lack of differentiation of the rat brain at birth has been shown some fifty years ago by Sugita1 in a classic paper on the postnatal morphogenesis of the brain in this animal. The sequence of physiological and biochemical changes which parallel the histological maturation of the rat brain has been investigated, however, only recently.

Molecular and kinetic properties of lactate dehydrogenase in the degenerating peripheral nerve

1966

Abstract Electrophoretic and catalytic studies have been carried out on lactate dehydrogenase of normal and transected sciatic nerves of the rat. Lactate dehydrogenase of the intact nerve exhibits an almost even distribution of activity among its component iso-enzymes. The complete transection of the nerve is responsible for a deep and immediate shift of the enzyme towards the so-called muscle type pattern. Seven days after the nerve section the percentage activity of iso-enzyme 5 is almost three times higher than in the intact nerve. After a short lag period lactate dehydrogenase specific activity (activity/mg protein) undergoes a sharp decrease in transected nerves. The return of the elec…

LACTATE DEHYDROGENASE ISOENZYMES IN THE NERVOUS TISSUE?V..

1965

LACTATE DEHYDROGENASE ISOENZYMES IN THE NERVOUS TISSUE. IV. AN ONTOGENETIC STUDY ON THE RAT BRAIN.

1964

Nicotinamide adenine dinucleotides in the convulsant rat brain

1970

Aspartate aminotransferase in brain tissue cultures

1969