0000000000482662

AUTHOR

Peter Huijser

showing 4 related works from this author

Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana

2015

Highlight Cyclic expression of copper transport and the responses to copper deficiency are integrated into the light and circadian–oscillator signalling in plants.

0106 biological sciencescopper deficiencyArabidopsis thalianaPhysiologyPeriod (gene)Circadian clockArabidopsischemistry.chemical_elementPlant Science01 natural sciencesdiurnal rhythm03 medical and health sciencesGene Expression Regulation Plantcircadian clockmedicineArabidopsis thalianaHomeostasisCircadian rhythmSLC31 Proteinsheavy metalsTranscription factorCation Transport Proteins030304 developmental biologyGeneticsheavy metals.0303 health sciencesbiologyArabidopsis ProteinsSuperoxide DismutaseGiganteafood and beveragesbiology.organism_classificationmedicine.diseasePlants Genetically ModifiedCopperCell biologyCircadian RhythmDNA-Binding Proteinschemistrycopper transportCopper deficiencyCopper010606 plant biology & botanyResearch PaperTranscription Factors
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Daily rhythmicity of high affinity copper transport

2016

A differential demand for copper (Cu) of essential cupro-proteins that act within the mitochondrial and chloroplastal electronic transport chains occurs along the daily light/dark cycles. This requires a fine-tuned spatiotemporal regulation of Cu delivery, becoming especially relevant under non-optimal growth conditions. When scarce, Cu is imported through plasma membrane-bound high affinity Cu transporters (COPTs) whose coding genes are transcriptionally induced by the SPL7 transcription factor. Temporal homeostatic mechanisms are evidenced by the presence of multiple light- and clock-responsive regulatory cis elements in the promoters of both SPL7 and its COPT targets. A model is presente…

0106 biological sciences0301 basic medicineCircadian clockArabidopsisComputingMilieux_LEGALASPECTSOFCOMPUTINGPlant Science01 natural sciencesElectron Transport03 medical and health sciencesGene Expression Regulation PlantArabidopsisBotanyRNA MessengerSLC31 ProteinsPromoter Regions GeneticCation Transport ProteinsTranscription factorbiologyArabidopsis ProteinsGiganteaTransporterPromoterbiology.organism_classificationElectron transport chainArticle AddendumCircadian RhythmTransport proteinDNA-Binding Proteins030104 developmental biologyBiophysicsCopperMetabolic Networks and PathwaysTranscription Factors010606 plant biology & botanyPlant Signaling & Behavior
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The Copper-microRNA Pathway Is Integrated with Developmental and Environmental Stress Responses in Arabidopsis thaliana

2021

As an essential nutrient, copper (Cu) scarcity causes a decrease in agricultural production. Cu deficiency responses include the induction of several microRNAs, known as Cu-miRNAs, which are responsible for degrading mRNAs from abundant and dispensable cuproproteins to economize copper when scarce. Cu-miRNAs, such as miR398 and miR408 are conserved, as well as the signal transduction pathway to induce them under Cu deficiency. The Arabidopsis thaliana SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE (SPL) family member SPL7 binds to the cis-regulatory motifs present in the promoter regions of genes expressed under Cu deficiency, including Cu-miRNAs. The expression of several other SPL transcription f…

copper-microRNAsSPLArabidopsis thalianaQH301-705.5Arabidopsischemistry.chemical_elementPlant DevelopmentEnvironmental stressCatalysisArticleInorganic ChemistrystressStress PhysiologicalmicroRNAArabidopsis thalianaPhysical and Theoretical ChemistryBiology (General)Molecular BiologyTranscription factorGeneQD1-999developmentSpectroscopybiologyArabidopsis Proteins<i>Arabidopsis thaliana</i>Organic ChemistryPromotercopper homeostasisGeneral Medicinebiology.organism_classificationCopperComputer Science ApplicationsCell biologyDNA-Binding ProteinsChemistryMicroRNAschemistrySignal transductionCopperTranscription Factors
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The Arabidopsis COPT6 Transport Protein Functions in Copper Distribution Under Copper-Deficient Conditions

2013

Copper (Cu), an essential redox active cofactor, participates in fundamental biological processes, but it becomes highly cytotoxic when present in excess. Therefore, living organisms have established suitable mechanisms to balance cellular and systemic Cu levels. An important strategy to maintain Cu homeostasis consists of regulating uptake and mobilization via the conserved family of CTR/COPT Cu transport proteins. In the model plant Arabidopsis thaliana, COPT1 protein mediates root Cu acquisition, whereas COPT5 protein functions in Cu mobilization from intracellular storage organelles. The function of these transporters becomes critical when environmental Cu bioavailability diminishes. Ho…

PhysiologyMolecular Sequence DataSaccharomyces cerevisiaeMutantArabidopsisSaccharomyces cerevisiaePlant SciencePlant RootsCofactorCell membraneGene Expression Regulation PlantArabidopsisOrganellemedicineHomeostasisAmino Acid SequenceSLC31 ProteinsbiologyArabidopsis ProteinsMembrane transport proteinCell MembraneGenetic Complementation TestMembrane Transport ProteinsBiological TransportCell BiologyGeneral MedicinePlants Genetically Modifiedbiology.organism_classificationUp-RegulationTransport proteinCell biologyPlant LeavesMutagenesis Insertionalmedicine.anatomical_structureBiochemistrySeedsbiology.proteinPlant Vascular BundleSequence AlignmentCopperPlant ShootsPlant and Cell Physiology
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