0000000000485028
AUTHOR
Francisco Vera Sempere
Mortality in early-stage, surgically resected non-small cell lung cancer less than 3cm of size: Competing risk analysis
Abstract Background and objective Survival studies of non-small cell lung cancer (NSCLC) are usually based on the Kaplan–Meier method. However, other factors not covered by this method may modify the observation of the event of interest. There are models of cumulative incidence (CI), that take into account these competing risks, enabling more accurate survival estimates and evaluation of the risk of death from other causes. We aimed to evaluate these models in resected early-stage NSCLC patients. Patients and method This study included 263 patients with resected NSCLC whose diameter was ≤3 cm without node involvement (N0). Demographic, clinical, morphopathological and surgical variables, TN…
In Memoriam : las aportaciones micrográficas del valenciano Luis Simarro (1851-1921)
El pasado 19 de junio del 2021, se cumplió el centenario de la muerte del histólogovalenciano Luis Simarro Lacabra (1851-1921). La figura de Simarro prácticamente ha desapare-cido, en el momento actual, de la memoria del panorama científico y cultural espa¿nol, siendo susaportaciones micrográficas escasamente conocidas, probablemente debido a que su produccióncientífica escrita fue muy reducida.En el presente trabajo, las aportaciones micrográficas de Simarro, de las que tenemos cono-cimiento, son revisadas en el contexto de su biografía, analizando su influencia en el origen ydesarrollo de la escuela neurohistológica española que, liderada por Santiago Ramón y Cajal,es hoy universalmente r…
Tumor del estroma gastrointestinal y schwannoma gástricos: una presentación inusual en un paciente sin neurofibromatosis
The majority of gastric neoplasms are of epithelial type. Stromal tumours are the next most frequent and are most commonly gastrointestinal stromal tumours, followed by leiomyoma and schwannoma. We present an exceptional case of a patient with a gastrointestinal stromal tumour with suspicion of residual gastric disease, which was diagnosed post-operatively as a schwannoma.
Tumoricidal Activity of Endothelial Cells
The mechanism of NO- and H(2)O(2)-induced tumor cytotoxicity was examined during B16 melanoma (B16M) adhesion to the hepatic sinusoidal endothelium (HSE) in vitro. We used endothelial nitric-oxide synthetase gene disruption and N(G)-nitro-l-arginine methyl ester-induced inhibition of nitric-oxide synthetase activity to study the effect of HSE-derived NO on B16M cell viability. Extracellular H(2)O(2) was removed by exogenous catalase. H(2)O(2) was not cytotoxic in the absence of NO. However, NO-induced tumor cytotoxicity was increased by H(2)O(2) due to the formation of potent oxidants, likely ( small middle dot)OH and (-)OONO radicals, via a trace metal-dependent process. B16M cells culture…