0000000000485161
AUTHOR
Jukka‐pekka Mecklin
Promoting inter‐professional teamwork and learning – the case of a surgical operating theatre
Hospitals, and surgical operating theatres (OTs) in particular, are environments in which inter‐professional teamwork and learning are essential to secure patient safety and effective practice. However, it has been revealed in many studies that inter‐professional collaborative work in hospital organisations faces many challenges and constraints. In this study we examine surgical operations as participatory practices from the perspective of inter‐professional learning and cooperation. We ask what kinds of shared practices enable learning and collaboration within the surgical operating team. We used an ethnographic approach to data collection including observations and interviews of surgical …
Is HLA type a possible cancer risk modifier in Lynch syndrome?
Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30-80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are characterized by the accumulation of frameshift mutations leading to highly immunogenic frameshift peptides (FSPs). Thus, immune surveillance is proposed to inhibit the outgrowth of MMR-deficient cell clones. Recent studies have shown that immunoediting during the evolution of MMR-deficient…