0000000000496429
AUTHOR
A. Mosset
Studies on metal-drug complexes. Crystal structure and characterization of μ-sulfato bromazepam copper(II) complex
Abstract The compound Cu(Bromazepam) SO 4 having been synthesized, its crystal structure shows distorted octahedral environment for the Copper(II) ion. Because of the long Cu-O(4) length (2.90 A), we can consider that there is a semicoordinative interaction with the sulfate group acting as tridentate bridging ligand. The structure is a polymeric chain where dimeric units are linked by the oxygen (C-O(5)) atom of the Bromazepam carbonyl group. The drug consequently acts as a tridentate ligand in this compound. The magnetic results show a very weak antiferromagnetic interaction.
LOCAL STRUCTURE OF THE CuCu (EDTA) (H2O)2, 2H2O AMORPHOUS COMPLEX : A JOINT MAGNETIC, LAXS, AND MOLECULAR MECHANICS INVESTIGATION
The short range order in the amorphous CuCu (EDTA) (H2O)2, 2H2O is studied by Large Angle X-ray Scattering (LAXS) and molecular mechanics. Three conformations of the complex molecule are shown to be energetically equivalent, two of which are simultaneously present in the amorphous material.