6533b821fe1ef96bd127c0ca

RESEARCH PRODUCT

Studies on metal-drug complexes. Crystal structure and characterization of μ-sulfato bromazepam copper(II) complex

José Antonio RealA. MossetM.c. MuñozJoaquín BorrásJean Galy

subject

chemistry.chemical_classificationBromazepamChemistryStereochemistrychemistry.chemical_elementBridging ligandCrystal structureBiochemistryCopperInorganic ChemistryMetalCrystallographyOctahedronvisual_artmedicinevisual_art.visual_art_mediumMoleculeInorganic compoundmedicine.drug

description

Abstract The compound Cu(Bromazepam) SO 4 having been synthesized, its crystal structure shows distorted octahedral environment for the Copper(II) ion. Because of the long Cu-O(4) length (2.90 A), we can consider that there is a semicoordinative interaction with the sulfate group acting as tridentate bridging ligand. The structure is a polymeric chain where dimeric units are linked by the oxygen (C-O(5)) atom of the Bromazepam carbonyl group. The drug consequently acts as a tridentate ligand in this compound. The magnetic results show a very weak antiferromagnetic interaction.

https://doi.org/10.1016/0162-0134(87)80007-7