0000000000496886

AUTHOR

Richard J. Rodeheffer

showing 4 related works from this author

Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.

2009

Context Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. Objective To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. Design, Setting, and Participants Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nuc…

AdultMalemedicine.medical_specialtyPathologyGenotypeHeart VentriclesPopulationLocus (genetics)Genome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideVentricular Function LeftWhite PeopleArticleVentricular Dysfunction LeftSDG 3 - Good Health and Well-beingRisk FactorsInternal medicineMedicineHumansHeart AtriaInternational HapMap ProjecteducationAortaAgedAged 80 and overeducation.field_of_studybusiness.industryGeneral MedicineOrgan SizeMiddle AgedPhenotypeCardiovascular DiseasesEchocardiographyMeta-analysisCohortCardiologyFemalebusinessCohort studyGenome-Wide Association StudyJAMA
researchProduct

A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community

2011

Objectives We sought to define the cardiometabolic phenotype associated with rs5068, a genetic variant of the atrial natriuretic peptide (ANP) gene. Background The ANP and B-type natriuretic peptide play an important role in cardiorenal homeostasis but also exert metabolic actions. Methods We genotyped 1,608 randomly selected residents from Olmsted County, Minnesota. Subjects were well-characterized. Results Genotype frequencies were: AA 89.9%, AG 9.7%, and GG 0.4%; all subsequent analyses were AA versus AG+GG. The G allele was associated with increased plasma levels of N-terminal pro-atrial natriuretic peptide (p = 0.002), after adjustment for age and sex. The minor allele was also associa…

Malemedicine.medical_specialtyLinkage disequilibriumSettore MED/09 - Medicina InternaGenotypemedicine.drug_classPopulationBlood PressureArticlemetabolic syndromeBody Mass IndexRandom AllocationAtrial natriuretic peptideInternal medicineatrial natriuretic peptidelipid metabolismNatriuretic Peptide BrainHomeostasimedicineNatriuretic peptideHomeostasisHumansAlleleeducationAllelesAgedAlleleeducation.field_of_studycardiometabolic diseasebusiness.industryGenetic VariationDNAMiddle Agedmedicine.diseaseEchocardiography DopplerGenotype frequencyProtein Structure TertiaryMinor allele frequencyEndocrinologyPhenotypeFemaleMetabolic syndromebusinessCardiology and Cardiovascular Medicinenatriuretic peptidesAtrial Natriuretic FactorHuman
researchProduct

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

2016

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation o…

0301 basic medicineNephrologyGenetics and Molecular Biology (all)estimated glomerular filtration rateestimated glomerular filtration rate chronic kidney disease genetic determinantsGeneral Physics and AstronomyKidney developmentGenome-wide association studyBiochemistrySettore MED/14 - NEFROLOGIARenal InsufficiencyChronicGeneticsAGEN Consortiumddc:616education.field_of_studyKidneyStage renal-diseaseMultidisciplinaryGenome-wide associationCHARGe-Heart Failure GroupGene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic; Genetic Predisposition to Disease; Biochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)QChemistry (all)MetaanalysisGene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Renal Insufficiency Chronic/geneticsBiological sciencesSerum creatininemedicine.anatomical_structureEfficientRonyons -- FisiologiaHypertensionICBP ConsortiumTransmembrane transporter activitygenetic association loci kidney functionCARDIOGRAMHumanmedicine.medical_specialtyGenotypeSciencePopulationRenal functionECHOGen ConsortiumReplicationBiologyEnvironmentResearch SupportGeneral Biochemistry Genetics and Molecular BiologyN.I.H.genetic determinants03 medical and health sciencesPhysics and Astronomy (all)GENOME-WIDE ASSOCIATION ; FALSE DISCOVERY RATES ; STAGE RENAL-DISEASE ; SERUM CREATININE ; METAANALYSIS ; VARIANTS ; INDIVIDUALS ; POPULATION ; RISK ; HYPERTENSIONKidney functionResearch Support N.I.H. ExtramuralInternal medicineMD MultidisciplinarymedicineGeneticsJournal ArticleHumanseGFRcrea; eGFRcysGenetic Predisposition to Diseaseddc:610GenetikRenal Insufficiency ChronicMortalityeducationddc:613Biochemistry Genetics and Molecular Biology (all)urogenital systemIndividualsExtramuralGeneral Chemistryta3121medicine.diseaseR1030104 developmental biologyGene Expression RegulationBiochemistry Genetics and Molecular Biology (all); Chemistry (all); Physics and Astronomy (all)570 Life sciences; biologyGenèticachronic kidney diseaseKidney diseaseGenome-Wide Association StudyMeta-Analysis
researchProduct

Human Hypertension Is Characterized by a Lack of Activation of the Antihypertensive Cardiac Hormones ANP and BNP

2012

ObjectivesThis study sought to investigate plasma levels of circulating cardiac natriuretic peptides, atrial natriuretic peptide (ANP) and B-type or brain natriuretic peptide (BNP), in the general community, focusing on their relative differences in worsening human hypertension.BackgroundAlthough ANP and BNP are well-characterized regulators of blood pressure in humans, little is known at the population level about their relationship with hypertension. The authors hypothesized that hypertension is associated with a lack of activation of these hormones or their molecular precursors.MethodsThe study cohort (N = 2,082, age >45 years) was derived from a random sample from Rochester, Minnesota, …

Malemedicine.medical_specialtySettore MED/09 - Medicina Internahypertensionmedicine.drug_class030204 cardiovascular system & hematologyCardiac hormonesArticle03 medical and health sciences0302 clinical medicineAtrial natriuretic peptideInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideHumanscardiovascular diseasesBNP; ANP; Human HypertensionAged030304 developmental biology0303 health sciencesnatriuretic peptideExtramuralbusiness.industryPlasma levelsMiddle AgedBrain natriuretic peptideSettore MED/11 - Malattie Dell'Apparato CardiovascolareproBNPEndocrinologyNT-proBNPHuman HypertensionLinear Modelscardiovascular systemFemaleCardiology and Cardiovascular MedicinebusinessAtrial Natriuretic Factorhormones hormone substitutes and hormone antagonistsANPcirculatory and respiratory physiologyBNPJournal of the American College of Cardiology
researchProduct