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RESEARCH PRODUCT
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
Jaap W. DeckersRobert ZweikerHenry VölzkeAndreas ZieglerInke R. KönigKarl WerdanBruno H. StrickerNorbert WatzingerPhilipp S. WildMaksim StruchalinGeorg HomuthJerome I. RotterThomas MeitingerMargaret M. RedfieldJohn S. GottdienerYurii S. AulchenkoHeyo K. KroemerLars LindSusan R. HeckbertRenate B. SchnabelTalin HarituniansHelena SchmidtRichard J. RodehefferNicholas L. SmithNicholas L. SmithMaria BlettnerJohannes HaertingHeribert SchunkertThomas MünzelIftikhar J. KulloCornelia M. Van DuijnDaniel LevyKarl J. LacknerUwe VölkerAnika GroßhennigEmelia J. BenjaminEmelia J. BenjaminKenneth RiceNicole L. GlazerMarcus DörrAbbas DehghanWolfgang LiebJoshua C. BisJacqueline C.m. WittemanBruce M. PsatyBruce M. PsatyJeanette ErdmannMartin G. LarsonMartin G. LarsonDonna K. ArnettJan StritzkeStephan B. FelixArne SchillertAndré G. UitterlindenJayashri AragamBlankenberg StefanThomas LumleyKarin Halina GreiserSekar KathiresanThomas J. WangRamachandran S. VasanRamachandran S. VasanGary F. MitchellNele FriedrichAlbert HofmanReinhold SchmidtFernando RivadeneiraJanine F. FelixErik IngelssonAlexander TeumerTanja ZellerThorsten ReffelmannH.-erich WichmannChristopher J. O'donnellsubject
AdultMalemedicine.medical_specialtyPathologyGenotypeHeart VentriclesPopulationLocus (genetics)Genome-wide association studySingle-nucleotide polymorphismPolymorphism Single NucleotideVentricular Function LeftWhite PeopleArticleVentricular Dysfunction LeftSDG 3 - Good Health and Well-beingRisk FactorsInternal medicineMedicineHumansHeart AtriaInternational HapMap ProjecteducationAortaAgedAged 80 and overeducation.field_of_studybusiness.industryGeneral MedicineOrgan SizeMiddle AgedPhenotypeCardiovascular DiseasesEchocardiographyMeta-analysisCohortCardiologyFemalebusinessCohort studyGenome-Wide Association Studydescription
Context Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. Objective To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. Design, Setting, and Participants Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nucleotide polymorphisms ( SNPs; imputed to the HapMap CEU panel) and echocardiographic traits. In stage 2, SNPs significantly associated with traits in stage 1 were tested for association in 2 other cohorts (n = 4094 people of European ancestry). Using a prespecified P value threshold of 5 x 10(-7) to indicate genome-wide significance, we performed an inverse variance-weighted fixed-effects meta-analysis of genome-wide association data from each cohort. Main Outcome Measures Echocardiographic traits: LV mass, internal dimensions, wall thickness, systolic dysfunction, aortic root, and left atrial size. Results In stage 1, 16 genetic loci were associated with 5 echocardiographic traits: 1 each with LV internal dimensions and systolic dysfunction, 3 each with LV mass and wall thickness, and 8 with aortic root size. In stage 2, 5 loci replicated (6q22 locus associated with LV diastolic dimensions, explaining < 1% of trait variance; 5q23, 12p12, 12q14, and 17p13 associated with aortic root size, explaining 1%-3% of trait variance). Conclusions We identified 5 genetic loci harboring common variants that were associated with variation in LV diastolic dimensions and aortic root size, but such findings explained a very small proportion of variance. Further studies are required to replicate these findings, identify the causal variants at or near these loci, characterize their functional significance, and determine whether they are related to overt cardiovascular disease. JAMA. 2009;302(2):168-178 www.jama.com
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 | JAMA |