0000000000499719

AUTHOR

S. Günzel

showing 4 related works from this author

(A)symptomatic necrotizing arteritis of the female genital tract.

2000

Abstract Aims: The vasculitides represent a heterogenous set of disorders that differ in prognosis and response to therapy. Beside systemic vasculitides, the development of localized forms of arteritis is well known though uncommon and the etiopathogenesis is not yet definitely clear. Methods: Patients with necrotizing arteritis of the female genital tract proven by histology are studied in a retrospective analysis. Results: Three cases of necrotizing arteritis with histological features of panarteritis nodosa apparently confined to the female genital tract are presented. None of these patients had prior history of systemic vasculitis. The acute necrotizing vasculitis was confined only to t…

Pathologymedicine.medical_specialtyCervix UteriNecrotizing VasculitismedicineHumansSex organArteritisMenorrhagiaFallopian TubesAgedRetrospective StudiesPolyarteritis nodosabusiness.industryVascular diseaseOvaryObstetrics and GynecologyGenitalia FemaleMiddle Agedmedicine.diseasePrognosisPolyarteritis NodosaReproductive MedicineMyometriumHistopathologyFemaleUterine HemorrhageVasculitisbusinessSystemic vasculitisEuropean journal of obstetrics, gynecology, and reproductive biology
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Human papillomavirus (HPV) DNA in primary cervical cancer and in cancer free pelvic lymph nodes--correlation with clinico-pathological parameters and…

2001

OBJECTIVE To assess whether the presence of human papilloma virus (HPV) DNA and/or several genotypes of HPV DNA in primary cervical cancer and cancer free pelvic lymph nodes are correlated with several clinicopathological parameters of well-defined prognostic significance and whether virological parameters are predictors of long-term survival in cancer patients. PATIENTS AND METHODS 223 cases of cervical cancer patients included in this retrospective study underwent follow-up evaluation. Survival and cause of death were examined for 204 (91.4%) patients, with a mean follow-up time of 4.4 years. HPV DNA was detected using the high sensitive polymerase chain reaction (PCR) method followed by …

OncologyAdultmedicine.medical_specialtyGenotypeUterine Cervical NeoplasmsAdenocarcinomaPolymerase Chain Reactionlaw.inventionCarcinoma AdenosquamouslawInternal medicineGenotypeMedicineHumansNeoplasm InvasivenessLymph nodePapillomaviridaePolymerase chain reactionAgedRetrospective StudiesCervical cancerAged 80 and overbusiness.industryPapillomavirus InfectionsObstetrics and GynecologyCancerMiddle Agedmedicine.diseasePrognosisPrimary tumorSurvival AnalysisKoilocyteTumor Virus Infectionsmedicine.anatomical_structureLymphatic MetastasisDNA ViralCarcinoma Squamous CellFemaleLymphLymph NodesbusinessFollow-Up StudiesZentralblatt fur Gynakologie
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The presence of HPV DNA in cervical cancer: correlation with clinico-pathologic parameters and prognostic significance: 10 years experience at the De…

2001

The objective of this study was to assess whether the presence of human papillomavirus (HPV) DNA and/or several genotypes of HPV DNA in cervical cancer are correlated with several clinicopathologic parameters of well-defined prognostic significance and whether virologic parameters are predictors of long-term survival in cancer patients. Two hundred twenty three cases of cervical cancer patients included in this retrospective study underwent follow-up evaluation. Survival and cause of death were examined for 204 (91.4%) patients, with a mean follow-up time of 4.4 years. HPV DNA was detected using the highly sensitive polymerase chain reaction (PCR) method followed by HPV DNA sequencing for H…

OncologyAdultmedicine.medical_specialtyGenotypeUterine Cervical NeoplasmsAdenocarcinomaPolymerase Chain Reactionlaw.inventionCarcinoma AdenosquamouslawInternal medicineGenotypemedicineCarcinomaHumansPapillomaviridaePapillomaviridaeSurvival analysisPolymerase chain reactionAgedRetrospective StudiesGynecologyCervical cancerAged 80 and overbiologybusiness.industryPapillomavirus Infectionsvirus diseasesObstetrics and GynecologyCancerMiddle Agedmedicine.diseasebiology.organism_classificationPrognosisSurvival Analysisfemale genital diseases and pregnancy complicationsTumor Virus InfectionsOncologyDNA ViralCarcinoma Squamous CellAdenocarcinomaFemalebusinessInternational journal of gynecological cancer : official journal of the International Gynecological Cancer Society
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Human Papillomavirus Type 33 E7 Peptides Presented by HLA-DR*0402 to Tumor-Infiltrating T Cells in Cervical Cancer

2000

ABSTRACTSeveral characteristics make human papillomavirus (HPV) amenable to vaccination. Anti-HPV-directed vaccines are based on the observation that HPV E6 and E7 oncoproteins are constitutively expressed in HPV-positive cervical cancer and may serve as tumor rejection antigens. Five HPV types (16, 18, 31, 33, and 45) account for 80% of cervical cancer. Until now, the type of immune response capable of mediating an effective antitumor response has not been defined. In order to define the anticancer-directed immune response in situ, we characterized CD4+and CD8+sorted T cells from peripheral blood lymphocytes, freshly harvested tumor tissue, and tumor-infiltrating lymphocytes (TIL) from a p…

CD4-Positive T-LymphocytesT-LymphocytesMolecular Sequence DataImmunologyAntigen presentationReceptors Antigen T-CellUterine Cervical NeoplasmsCD8-Positive T-LymphocytesMajor histocompatibility complexMicrobiologyEpitopeEpitopesInterferon-gammaLymphocytes Tumor-InfiltratingImmune systemAntigenVirologymedicineHumansAmino Acid SequencePapillomaviridaePapillomaviridaeCervical cancerAntigen PresentationbiologyHLA-DR AntigensOncogene Proteins ViralFlow Cytometrymedicine.diseasebiology.organism_classificationImmunohistochemistryPeptide FragmentsInsect ScienceImmunologybiology.proteinCancer researchPathogenesis and ImmunityFemaleCD8Journal of Virology
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