Tracking progression from pre-MCI to dementia: a decade of pre-diagnostic assessment in a case of Familial Alzheimer's disease

The natural history of Alzheimer disease: a longitudinal presymptomatic and symptomatic study of a familial cohort

BACKGROUND: Knowledge of the evolution of cognitive deficits in Alzheimer disease is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stages. OBJECTIVE: To delineate the onset and progression of clinical and neuropsychological abnormalities in familial Alzheimer disease. METHODS: Nineteen subjects with familial Alzheimer disease underwent serial clinical and neuropsychological assessments. Eight of these had undergone presymptomatic assessments. The follow-up period was 1 to 10 years (mean, 5 years). The relative timing of the occurrence of 3 markers of disease onset and progression (onset of …

A decade of prediagnostic assessment in a case of Familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia