0000000000504722
AUTHOR
F. Durst
Effect of a suicide-substrate of cytochrome P-450 on the metabolism of phenylureas in wheat plants
National audience
Effect of the cytochrome P-450 inactivator 1-aminobenzotriazole on the metabolism of chlortoluron and isoproturon in wheat
Abstract Roots of young wheat plants ( Triticum aestivum cv Clement) were treated with [ 14 C]chlortoluron or [ 14 C]isoproturon alone or mixed with 1-aminobenzotriazole (ABT), a mechanism-based inactivator of cytochrome P -450 monooxygenases. Radioactivity extracted from shoots slightly decreased during periods of metabolism, this decrease being reduced by ABT in the case of isoproturon. ABT strongly inhibited the metabolism of both herbicides. Accumulation of metabolites was generally depressed in the presence of ABT; however, levels of the free N -monodemethylated derivatives were little or not affected. It is concluded that ABT is a synergist of chlortoluron and isoproturon in wheat bec…
Effect of mixed function oxidase inhibitors on the toxicite chlortoluron and isoproturon to wheat
International audience