0000000000511741

AUTHOR

Alma Joel

showing 2 related works from this author

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax.

2010

The subterranean mole rat Spalax is an excellent model for studying adaptation of a mammal toward chronic environmental hypoxia. Neuroglobin (Ngb) and cytoglobin (Cygb) are O 2 -binding respiratory proteins and thus candidates for being involved in molecular hypoxia adaptations of Spalax . Ngb is expressed primarily in vertebrate nerves, whereas Cygb is found in extracellular matrix-producing cells and in some neurons. The physiological functions of both proteins are not fully understood but discussed with regard to O 2 supply, the detoxification of reactive oxygen or nitrogen species, and apoptosis protection. Spalax Ngb and Cygb coding sequences are strongly conserved. However, mRNA and …

SpalaxNeuroglobinNerve Tissue ProteinsBiologyRats Sprague-DawleyExtracellularAnimalsHumansGlobinHypoxiaRegulation of gene expressionMessenger RNAMultidisciplinaryBase SequenceMyoglobinCytoglobinCytoglobinAnatomySequence Analysis DNABiological Sciencesbiology.organism_classificationAdaptation PhysiologicalCell biologyGlobinsRatsGene Expression RegulationApoptosisNeuroglobinSpalaxProceedings of the National Academy of Sciences of the United States of America
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Genomic Organization and Molecular Evolution of the Genes for Neuroglobin and Cytoglobin in the Hypoxiatolerant Israeli Mole Rat, Spalax Carmeli

2006

The genes for the two respiratory proteins neuroglobin (Ngb) and cytoglobin (Cygb) in the subterranean Israeli mole rat Spalax carmeli have been sequenced and compared to other mammals including human. Coding regions of both Spalax genes are highly conserved on the nucleotide and amino acid level. The ratios of non-synonymous to synonymous nucleotide substitutions suggest strong purifying selection acting on Ngb and Cygb in all mammals. Thus, there appears to be no special sequence level adaptation in the two respiratory proteins within the hypoxia-tolerant mole rat. On the genomic level, Spalax Ngb and Cygb gene regions revealed the conserved 4-exon-3-intron structure and conserved CpG-ric…

GeneticsDNA binding sitebiologySpalaxMolecular evolutionNeuroglobinCytoglobinIntronAnimal Science and Zoologybiology.organism_classificationGeneEcology Evolution Behavior and SystematicsGenomic organizationIsrael Journal of Ecology and Evolution
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