Manipulations of glucocorticoid induced stress response may differently affect the acquisition of a reward-facilitated spatial-visual learning task.

The neurosteroids sulfate PREGS and DHEAS exert a facilitative role in learning performance in male rats.

Manipulations of glucocorticoids induced stress response may differently affect the acquisition of a reward-facilitated spatially/visual learning task.

The neurosteroids sulphate PREGS and DHEAS exert a facilitative role on learning performance in adult male rats

Pregnenolone sulphate faciltates object recognition and reduces depressive-like behaviour in male adult rats

Manipulatios of glucocortioid induced stress response may differently affect the acquisition of a reward-facilitated spatial/visual learning task

The neurosteroids DHEAS and PREGS may affect learning performance by altering affective state

The neurosteroids sulfate pregs and DHEAS selectively improve memory retention in adult female rats

Neurosteroid PREGS differently affects learning and memory performance by altering emotionality in a gender-related manner

The neurosteroids PREGS and DHEAS selectively improve memory retention in adult female rats.

Neurosteroid PREGS differently affects learning and memory performance by altering emotionality in a gender-related manner. 4th International Meeting Steroids and Nervous System, Torino, Italy. Febbrary 17-21 (2007)

The neurosteroids sulfate PREGS and DHEAS exert a facilitative role in learning performance in adult male rats

Effect of Acetaldehyde on CRF release form incubated hypothalamic explants

In the past, Acetaldehyde (ACD), the main metabolite of ethanol (ETOH), was mainly studied for its toxic and adverse effects (1). However, recently, ACD was reported to determine behavioural and neurochemical effects, following ETOH assumption in rodents (2, 3). Indeed, ACD enhances dopamine levels in nucleus accumbens, stimulates beta-endorphin release from hypothalamic cells, mediating alcohol reinforcing effects (4). Since little is known about the effects of ACD on other central neuropeptides, in this research we aimed to investigate ACD influence on hypothalamic corticotropin-releasing factor (CRF) release. In order to ascertain this hypothesis, different doses of ACD (1, 10, 3x10 micr…