Cocleo-labirintopatie nel bambino. Come non perdere l'equilibrio.

Cochleo-labyrinthopathy (CL) is an affection that involves cochlea and vestibular system. It occurs with the association of auditory symptoms (sensorineural hearing loss and tinnitus), vestibular symptoms (objective vertigo, unidirectional horizontal-rotary nystagmus and static or dynamic balance disorders) and neurovegetative signs (nausea, vomiting, pallor, sweating, etc.). The diagnosis may be difficult in paediatric age since the child is unable to clearly express their discomfort and symptoms. Multiple causes have been recognized but, in acute cases, infection is the most frequent etiological agent. The paper describes a case of CL due to Herpes Virus 1-2 infection responsive to acyclo…

Preventive Effect of Cow's Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multicenter Randomized Controlled Trial

Background: Fermented foods have been proposed to prevent common infectious diseases (CIDs) in children attending day care or preschool. Objectives: To investigate the efficacy of dietary supplementation with cow’s skim milk fermented with the probiotic Lactobacillus paracasei CBA L74 in reducing CIDs in children attending day care or preschool. Methods: Multicenter, randomized, double-blind, placebo-controlled trial on healthy children (aged 12–48 months) consuming daily 7 grams of cow’s skim milk fermented with L. paracasei CBA L74 (group A), or placebo (maltodextrins group B) attending day care or preschool during the winter season. The main outcome was the proportion of children who exp…

Effect of fermented milk with Lactobacillus paracasei CBA L74 on gastrointestinal and respiratory infections in children: multicenter randomized controlled trial

4p16.1-p15.31 duplication and 4p terminal deletion in a 3-years old Chinese girl: Array-CGH, genotype-phenotype and neurological characterization

Abstract Background Microscopically chromosome rearrangements of the short arm of chromosome 4 include the two known clinical entities: partial trisomy 4p and deletions of the Wolf-Hirschhorn critical regions 1 and 2 (WHSCR-1 and WHSCR-2, respectively), which cause cranio-facial anomalies, congenital malformations and developmental delay/intellectual disability. Methods/results We report on clinical findings detected in a Chinese patient with a de novo 4p16.1-p15.32 duplication in association with a subtle 4p terminal deletion of 6 Mb in size. This unusual chromosome imbalance resulted in WHS classical phenotype, while clinical manifestations of 4p trisomy were practically absent. Conclusio…

Prevalence of functional gastrointestinal disorders in young Belgian, Dutch and Italian children: Preliminary data

Strategie di prevenzione dell’aterosclerosi in età pediatrica

Riassunto La prevenzione dell’aterosclerosi in eta pediatrica prevede l’adozione di abitudini alimentari e stili di vita salubri e il monitoraggio, gia dalla prima infanzia, del peso corporeo, del profilo lipidico e della pressione arteriosa. In questo articolo abbiamo descritto le attuali raccomandazioni in tema di prevenzione per l’intera comunita pediatrica e, in particolare, per i bambini ad alto rischio, valutando in questi ultimi la possibilita di prescrivere statine. L’utilizzo di questi farmaci e ancora oggi oggetto di controversie nonostante le recenti raccomandazioni dell’American Academy of Pediatrics.