0000000000514551
AUTHOR
Carolina Lopez Alayon
Mise au point d’un modèle de co-culture cellules entérocytes et d’un modèle de colonisation digestive stable chez la souris immuno-compétente permettant d’étudier les interactions cellulaires et moléculaires in vitro et in vivo de C. albicans avec la muqueuse digestive
National audience
Candida albicans interaction with M cells in an in vitro model of the human intestinal Follicle Associated Epithelium (FAE)
National audience; Candida albicans (C. albicans) is a microorganism belonging to the commensal flora of the intestinal, oral and vaginal mucosal surfaces in healthy humans. This commensalism results from a balance between the virulence factors of the yeast and defense mechanisms of the host. However, disturbance of this balance in a vulnerable patient may result in intense mucosal colonization that promotes invasion of epithelial cells, translocation across the intestinal epithelial barrier and, eventually hematogenous dissemination. A better understanding of the mechanisms by which C. albicans interacts with the intestinal mucosa will improve our knowledge of the physiopathology of dissem…