0000000000514554
AUTHOR
Delphine Croisier-bertin
showing 4 related works from this author
Mise au point d’un modèle de co-culture cellules entérocytes et d’un modèle de colonisation digestive stable chez la souris immuno-compétente permett…
2012
National audience
Mise en place d'un modèle in vivo de colonisation digestive stable à C. Abicans chez la souris immunocompétente
2012
Les levures du genre Candida sont des agents pathogènes opportunistes responsables de candidoses invasives chez les sujets immunodéprimés, et sont associées à un taux de mortalité élevé. Elles représentent 8 à 15% des infections nosocomiales hématogènes et Candida albicans est l’espèce la plus fréquemment isolée en pathologie humaine. Initialement C. albicans appartient à la flore commensale intestinale, buccale et vaginale de l’homme. Ce commensalisme résulte d’un équilibre entre les propriétés biologiques de la levure et les systèmes de défense de l’hôte. La rupture de cet équilibre chez un patient fragilisé aura pour conséquence une colonisation intense des muqueuses favorisant un envahi…
Generic vancomycin products: Analysis of serum concentrations in patients with acute myeloid leukemia.
2013
Summary Concerns have recently emerged about the quality of generic vancomycin products. Our aim is to analyze serum vancomycin concentrations measured 48 hours after the start of an empirical treatment regimen in patients with acute myeloid leukemia (AML) who received one of the two generic vancomycin products available in France. Patients and methods Seventy-nine AML patients treated with vancomycin during two study periods were included in the study. Our vancomycin dosing regimen was based on the patients’ total body weight adjusted for renal clearance. Results A total of 93 serum vancomycin concentrations were collected: 31 in period 1 and 62 in period 2. In bivariate analysis, the mean…
Impact of the Prone Position in an Animal Model of Unilateral Bacterial Pneumonia Undergoing Mechanical Ventilation
2013
Abstract Background: The prone position (PP) has proven beneficial in patients with severe lung injury subjected to mechanical ventilation (MV), especially in those with lobar involvement. We assessed the impact of PP on unilateral pneumonia in rabbits subjected to MV. Methods: After endobronchial challenge with Enterobacter aerogenes, adult rabbits were subjected to either “adverse” (peak inspiratory pressure = 30 cm H2O, zero end-expiratory pressure; n = 10) or “protective” (tidal volume = 8 ml/kg, 5 cm H2O positive end-expiratory pressure; n = 10) MV and then randomly kept supine or turned to the PP. Pneumonia was assessed 8 h later. Data are presented as median (interquartile range). Re…