0000000000514556

AUTHOR

Davy Hayez

showing 2 related works from this author

Mechanical ventilation alters the development of staphylococcus aureus pneumonia in rabbit

2016

Ventilator-associated pneumonia (VAP) is common during mechanical ventilation (MV). Beside obvious deleterious effects on muco-ciliary clearance, MV could adversely shift the host immune response towards a pro-inflammatory pattern through toll-like receptor (TLRs) up-regulation. We tested this hypothesis in a rabbit model of Staphylococcus aureus VAP. Pneumonia was caused by airway challenge with S. aureus, in either spontaneously breathing (SB) or MV rabbits (n = 13 and 17, respectively). Pneumonia assessment regarding pulmonary and systemic bacterial burden, as well as inflammatory response was done 8 and 24 hours after S. aureus challenge. In addition, ex vivo stimulations of whole blood…

0301 basic medicinePulmonologyPhysiologyStaphylococcusmedicine.medical_treatment[SDV]Life Sciences [q-bio]lcsh:MedicinePharmacologyPathology and Laboratory Medicinemedicine.disease_causeStaphylococcal/immunology/pathologyImmune ReceptorsBiochemistry0302 clinical medicineImmune PhysiologyPneumonia StaphylococcalMedicine and Health SciencesMedicineStaphylococcus Aureuslcsh:ScienceImmune ResponseToll-like ReceptorsMammalsddc:616Innate Immune SystemImmune System ProteinsMultidisciplinaryddc:617RespirationPneumonia Ventilator-AssociatedInterleukinAnimal ModelsHematologyBacterial PathogensBody Fluids3. Good healthBloodmedicine.anatomical_structureMedical MicrobiologyStaphylococcus aureusVertebratesArtificialCytokinesRabbitsPathogensAnatomymedicine.symptomStaphylococcus aureus/immunologyResearch ArticleSignal TransductionToll-Like Receptor 2/immunologyImmunologyInflammationLung injuryResearch and Analysis MethodsMicrobiology03 medical and health sciencesModel OrganismsSigns and SymptomsDiagnostic MedicineAnimalsMicrobial PathogensInflammationMechanical ventilationInterleukin-8/immunologyLung[ SDV ] Life Sciences [q-bio]BacteriaTumor Necrosis Factor-alphabusiness.industrylcsh:RInterleukin-8OrganismsBiology and Life SciencesProteins030208 emergency & critical care medicineCell BiologyPneumoniaMolecular Developmentmedicine.diseaseTumor Necrosis Factor-alpha/immunologyRespiration ArtificialToll-Like Receptor 2Pneumonia030104 developmental biologyVentilator-Associated/immunology/microbiology/pathologyImmune SystemAmniotesImmunologylcsh:QbusinessSpleenEx vivoDevelopmental Biology
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Mise au point d’un modèle de co-culture cellules entérocytes et d’un modèle de colonisation digestive stable chez la souris immuno-compétente permett…

2012

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[SDV] Life Sciences [q-bio][SDE] Environmental Sciences[SDV]Life Sciences [q-bio][SDE]Environmental Sciences[SDV.BV]Life Sciences [q-bio]/Vegetal Biology[SDV.BV] Life Sciences [q-bio]/Vegetal BiologyComputingMilieux_MISCELLANEOUS
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