0000000000515778

AUTHOR

Celia Incerti

showing 2 related works from this author

ChemInform Abstract: Enantioselective LaIII-pyBOX-Catalyzed Nitro-Michael Addition to (E)-2-Azachalcones.

2013

A [La(OTf)3] complex with a new pyBOX ligand bearing a bulky 1-naphthylmethyl substituent at the 4′-position of the oxazoline ring catalyzes the conjugate addition of nitroalkanes to a broad range of (E)-2-azachalcones, providing the expected nitro-Michael products with good yields and enantiomeric excesses up to 87 %. The optical purity of the products can be increased by a single crystallization. A plausible stereochemical model to account for the observed stereochemistry has been proposed.

chemistry.chemical_compoundAddition reactionChemistryLigandMichael reactionSubstituentNitroEnantioselective synthesisGeneral MedicineOxazolineEnantiomeric excessMedicinal chemistryChemInform
researchProduct

Enantioselective LaIII-pyBOX-Catalyzed Nitro-Michael Addition to (E)-2-Azachalcones

2013

A [La(OTf)3] complex with a new pyBOX ligand bearing a bulky 1-naphthylmethyl substituent at the 4′-position of the oxazoline ring catalyzes the conjugate addition of nitroalkanes to a broad range of (E)-2-azachalcones, providing the expected nitro-Michael products with good yields and enantiomeric excesses up to 87 %. The optical purity of the products can be increased by a single crystallization. A plausible stereochemical model to account for the observed stereochemistry has been proposed.

chemistry.chemical_compoundchemistryLigandStereochemistryOrganic ChemistryNitroEnantioselective synthesisMichael reactionSubstituentOxazolinePhysical and Theoretical ChemistryEnantiomerEnantiomeric excessEuropean Journal of Organic Chemistry
researchProduct