0000000000517498
AUTHOR
Mohit Navandar
Low-cost scalable discretization, prediction and feature selection for complex systems
The introduced data-driven tool allows simultaneous feature selection, model inference, and marked cost and quality gains.
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemogenetic inhibition of neuronal activity in the mPFC-NAc pathway induces compulsive food seeking. Transcriptomic analysis and genetic manipulation identified that increased dopamine D2 receptor express…