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RESEARCH PRODUCT
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
Elena Martín-garcíaElena Martín-garcíaSarah BaddenhausenSusanne GerberClementine HofmannEric SenabreEduardo DomínguezIrene SerraRaül AnderoRaül AnderoInigo Ruiz De AzuaInigo Ruiz De AzuaLaura Domingo-rodriguezSami KummerRafael MaldonadoMarta NavarreteMohit NavandarBeat LutzBeat LutzMara Dierssensubject
0301 basic medicineFood addictionSciencemedicine.medical_treatmentPrefrontal CortexAddictionGeneral Physics and AstronomyNucleus accumbensNeurotransmissionBiologySynaptic TransmissionNucleus AccumbensArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesGlutamatergic0302 clinical medicineReceptor Cannabinoid CB1Dopamine receptor D2Behavioural genetics ; AddictionNeural Pathwaysmental disordersmedicineAnimalsPremovement neuronal activitylcsh:SciencePrefrontal cortexMice KnockoutMultidisciplinaryReceptors Dopamine D2Gene Expression ProfilingQdigestive oral and skin physiologyFeeding BehaviorGeneral ChemistryUp-RegulationDisease Models Animal030104 developmental biologyGene Expression RegulationBehavioural geneticslcsh:QFood AddictionCannabinoidNeuroscience030217 neurology & neurosurgerydescription
Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemogenetic inhibition of neuronal activity in the mPFC-NAc pathway induces compulsive food seeking. Transcriptomic analysis and genetic manipulation identified that increased dopamine D2 receptor expression in the mPFC-NAc pathway promotes the addiction-like phenotype. Our study unravels a new neurobiological mechanism underlying resilience and vulnerability to the development of food addiction, which could pave the way towards novel and efficient interventions for this disorder.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-06-12 |