0000000000319218

AUTHOR

Clementine Hofmann

showing 6 related works from this author

Maternal Caloric Restriction Implemented during the Preconceptional and Pregnancy Period Alters Hypothalamic and Hippocampal Endocannabinoid Levels a…

2016

Journal Article; Exposure to inadequate nutritional conditions in critical windows of development has been associated to disturbances on metabolism and behavior in the offspring later in life. The role of the endocannabinoid system, a known regulator of energy expenditure and adaptive behaviors, in the modulation of these processes is unknown. In the present study, we investigated the impact of exposing rat dams to diet restriction (20% less calories than standard diet) during pre-gestational and gestational periods on: (a) neonatal outcomes; (b) endocannabinoid content in hypothalamus, hippocampus and olfactory bulb at birth; (c) metabolism-related parameters; and (d) behavior in adult mal…

0301 basic medicineLitter (animal)hippocampuschemistry.chemical_compoundBehavioral Neuroscience0302 clinical medicineMaternal urdernutrition:Phenomena and Processes::Metabolic Phenomena::Body Composition::Body Fat Distribution::Adiposity [Medical Subject Headings]rathypothalamus:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]Original Research:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Adaptation Psychological [Medical Subject Headings]Endocannabinoid systemOlfactory BulbEndocannabinoidesNeuropsychology and Physiological PsychologyAdiposidadGestationmedicine.symptomRestricción calórica:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Arachidonic Acids [Medical Subject Headings]medicine.medical_specialtyOffspringEmbarazo:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake::Caloric Restriction [Medical Subject Headings]Cognitive NeuroscienceHypothalamusBiologyDevelopmentlcsh:RC321-57103 medical and health sciencesAnsiedadRatasHyppocampusInternal medicinemedicineHipocampoÁcidos araquidónicos:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]endocannabinoids:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety [Medical Subject Headings]lcsh:Neurosciences. Biological psychiatry. NeuropsychiatrydevelopmentPregnancyPalmitoylethanolamideBehavior:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoids [Medical Subject Headings]behaviorMetabolismo Energético:Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism [Medical Subject Headings]maternal undernutrition:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings]medicine.diseaseAdaptación psicológicaOlfactory bulb030104 developmental biologyEndocrinologyMetabolism:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]chemistryRatWeight gainmetabolism030217 neurology & neurosurgeryHipotálamoEndocannabinoidsNeuroscienceFrontiers in Behavioral Neuroscience
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The CB1Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

2012

The generation and specification of pyramidal neuron subpopulations during development relies on a complex network of transcription factors. The CB1cannabinoid receptor is the major molecular target of endocannabinoids and marijuana active compounds. This receptor has been shown to influence neural progenitor proliferation and axonal growth, but its involvement in neuronal differentiation and the functional impact in the adulthood caused by altering its signaling during brain development are not known. Here we show that the CB1receptor, by preventing Satb2 (special AT-rich binding protein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter activity, and Ctip2-po…

Pyramidal tractsCannabinoid receptorGeneral Neurosciencemedicine.medical_treatmentCellular differentiationBiologyMotor neuronEndocannabinoid systemArticleGlutamatergicmedicine.anatomical_structurenervous systemCorticospinal tractmedicinelipids (amino acids peptides and proteins)CannabinoidNeuroscienceThe Journal of Neuroscience
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Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus

2018

Abstract Neural stem cells (NSCs) in the adult mouse hippocampus occur in a specific neurogenic niche, where a multitude of extracellular signaling molecules converges to regulate NSC proliferation as well as fate and functional integration. However, the underlying mechanisms how NSCs react to extrinsic signals and convert them to intracellular responses still remains elusive. NSCs contain a functional endocannabinoid system, including the cannabinoid type-1 receptor (CB1). To decipher whether CB1 regulates adult neurogenesis directly or indirectly in vivo, we performed NSC-specific conditional inactivation of CB1 by using triple-transgenic mice. Here, we show that lack of CB1 in NSCs is su…

Male0301 basic medicineCell signalingCannabinoid receptorNeurogenesisCognitive NeuroscienceLong-Term PotentiationMice Transgenicmouse hippocampus ; neural stem cells ; neurogenesis-dependent behavior ; CB1 ; adult neurogenesisHippocampal formationBiologyHippocampus03 medical and health sciencesCellular and Molecular Neurosciencemouse hippocampus0302 clinical medicineNeural Stem CellsReceptor Cannabinoid CB1Animalsreproductive and urinary physiologySpatial MemoryBehavior AnimalNeurogenesisLong-term potentiationOriginal ArticlesCB1Endocannabinoid systemneurogenesis-dependent behaviorNeural stem cellCell biologyadult neurogenesisMice Inbred C57BL030104 developmental biologynervous systemlipids (amino acids peptides and proteins)biological phenomena cell phenomena and immunityStem cell030217 neurology & neurosurgeryCerebral Cortex
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A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampu…

2017

Existe para su consulta material suplementario aportado por el editor. Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring. We focused on brain structures involved in metabolism, feeding behavior, as well as em…

Male0301 basic medicineLitter (animal)Desnutrición:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Olfactory Pathways::Olfactory Bulb [Medical Subject Headings]:Organisms::Eukaryota::Animals::Animal Population Groups::Animals Newborn [Medical Subject Headings]Ácido Araquidónicolcsh:MedicineHippocampusBiochemistry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Size::Body Weight::Birth Weight [Medical Subject Headings]Oleoylethanolamidechemistry.chemical_compound0302 clinical medicinePregnancyMedicine and Health Sciences:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats Wistar [Medical Subject Headings]MasculinoPeso al nacerlcsh:Science:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]MultidisciplinaryFemeninoBrainNeurochemistryPlantsLegumesLipidsOlfactory BulbEndocannabinoid systemEndocannabinoidesEncéfaloHypothalamusEmocionesFemalelipids (amino acids peptides and proteins)Restricción calóricaNeurochemicalsAnatomy:Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Arachidonic Acids [Medical Subject Headings]Research ArticleBulbo olfatoriomedicine.medical_specialtyEmbarazoAnimales recién nacidos:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake::Caloric Restriction [Medical Subject Headings]OffspringHypothalamus:Check Tags::Male [Medical Subject Headings]Biology03 medical and health sciencesInternal medicineHipocampomedicineAnimals:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Endocannabinoids [Medical Subject Headings]Rats WistarCaloric RestrictionNutritionPregnancyPalmitoylethanolamideCognición:Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition [Medical Subject Headings]Ratas wistarlcsh:RMalnutritionOrganismsPeasBiology and Life Sciences:Anatomy::Nervous System::Central Nervous System::Brain [Medical Subject Headings]:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus [Medical Subject Headings]Lipid Metabolismmedicine.diseaseRatsDietOlfactory bulb030104 developmental biologyEndocrinology:Check Tags::Female [Medical Subject Headings]Animals Newbornnervous systemchemistry:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions [Medical Subject Headings]lcsh:QHipotálamo030217 neurology & neurosurgeryEndocannabinoidsNeurosciencePLOS ONE
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Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels…

2016

Journal Article; Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypotha…

0301 basic medicine:Phenomena and Processes::Genetic Phenomena::Phenotype [Medical Subject Headings]hippocampus:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Postpartum Period::Lactation [Medical Subject Headings]Anxiety:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Fat Distribution::Adiposity [Medical Subject Headings]Hippocampus:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Food Preferences [Medical Subject Headings]Open fieldBehavioral NeuroscienceOleoylethanolamidechemistry.chemical_compound:Named Groups::Persons::Parents::Mothers [Medical Subject Headings]0302 clinical medicineLactation:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure [Medical Subject Headings]maternal diethypothalamusMasculinoOriginal Research:Phenomena and Processes::Physiological Phenomena::Physiological Processes::Nutrition Processes::Weaning [Medical Subject Headings]Adipogenesis:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons Acyclic::Alkenes::Polyunsaturated Alkamides [Medical Subject Headings]AnandamideanxietyEndocannabinoid systemEtanolaminasEndocannabinoidesExposición maternaAlcamidas poliinsaturadasNeuropsychology and Physiological Psychologymedicine.anatomical_structureAdiposidad:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Fatty Acids Monounsaturated::Oleic Acids [Medical Subject Headings]CannabinoidesEmocionesGestationDieta:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Endocannabinoids [Medical Subject Headings]Fenotipo:Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Palmitic Acids [Medical Subject Headings]:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Arachidonic Acids [Medical Subject Headings]medicine.medical_specialtyOffspringCognitive NeurosciencePreferencias alimentariasHypothalamus:Check Tags::Male [Medical Subject Headings]Development:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings]Biologylcsh:RC321-571adipogenesisÁcidos oléicosAnsiedadRatas03 medical and health sciencesInternal medicineHipocampomedicineMaternal diet:Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings]endocannabinoids:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety [Medical Subject Headings]lcsh:Neurosciences. Biological psychiatry. NeuropsychiatrydevelopmentÁcido araquidónicoCacaoPalmitoylethanolamideLactancia:Chemicals and Drugs::Organic Chemicals::Amines::Amino Alcohols::Ethanolamines [Medical Subject Headings]:Chemicals and Drugs::Lipids::Glycerides [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings]030104 developmental biologyEndocrinologychemistryDestete:Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Sterculiaceae::Cacao [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions [Medical Subject Headings]MadresGlicéridosÁcidos palmíticos030217 neurology & neurosurgeryEndocannabinoidsNeuroscienceFrontiers in Behavioral Neuroscience
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A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction

2019

Food addiction is linked to obesity and eating disorders and is characterized by a loss of behavioral control and compulsive food intake. Here, using a food addiction mouse model, we report that the lack of cannabinoid type-1 receptor in dorsal telencephalic glutamatergic neurons prevents the development of food addiction-like behavior, which is associated with enhanced synaptic excitatory transmission in the medial prefrontal cortex (mPFC) and in the nucleus accumbens (NAc). In contrast, chemogenetic inhibition of neuronal activity in the mPFC-NAc pathway induces compulsive food seeking. Transcriptomic analysis and genetic manipulation identified that increased dopamine D2 receptor express…

0301 basic medicineFood addictionSciencemedicine.medical_treatmentPrefrontal CortexAddictionGeneral Physics and AstronomyNucleus accumbensNeurotransmissionBiologySynaptic TransmissionNucleus AccumbensArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesGlutamatergic0302 clinical medicineReceptor Cannabinoid CB1Dopamine receptor D2Behavioural genetics ; AddictionNeural Pathwaysmental disordersmedicineAnimalsPremovement neuronal activitylcsh:SciencePrefrontal cortexMice KnockoutMultidisciplinaryReceptors Dopamine D2Gene Expression ProfilingQdigestive oral and skin physiologyFeeding BehaviorGeneral ChemistryUp-RegulationDisease Models Animal030104 developmental biologyGene Expression RegulationBehavioural geneticslcsh:QFood AddictionCannabinoidNeuroscience030217 neurology & neurosurgery
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