0000000000519303

AUTHOR

Glen A. Evans

showing 2 related works from this author

Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.

1997

Abstract Histones are thought to play a key role in regulating gene expression at the level of DNA packaging. Recent evidence suggests that transcriptional activation requires competition of transcription factors with histones for binding to regulatory regions and that there may be several mechanisms by which this is achieved. We have characterized a human nucleosome assembly protein, NAP-2, previously identified by positional cloning at 11p15.5, a region implicated in several disease processes including Wilms tumor (WT) etiology. The deduced amino acid sequence of NAP-2 indicates that it encodes a protein with a potential nuclear localization motif and two clusters of highly acidic residue…

NAP1L4DNA ComplementaryNucleosome assemblyPositional cloningMolecular Sequence DataMice NudeWilms TumorHistonesMicemental disordersGeneticsNucleosomeAnimalsHumansAmino Acid SequenceCloning MolecularRegulation of gene expressionbiologyBase Sequencemusculoskeletal neural and ocular physiologyfungiGene Transfer TechniquesNuclear ProteinsMolecular biologyRecombinant ProteinsChromatinCell biologyNucleosomesDNA-Binding ProteinsHistoneChaperone (protein)biology.proteinpsychological phenomena and processesMolecular ChaperonesProtein BindingSubcellular FractionsGenomics
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Search for bottom-squark pair production in pp collision events at s=13  TeV with hadronically decaying τ -leptons, b -jets, and missing transverse m…

2021

A search for pair production of bottom squarks in events with hadronically decaying τ-leptons, b-tagged jets, and large missing transverse momentum is presented. The analyzed dataset is based on proton-proton collisions at s=13 TeV delivered by the Large Hadron Collider and recorded by the ATLAS detector from 2015 to 2018, and corresponds to an integrated luminosity of 139 fb-1. The observed data are compatible with the expected Standard Model background. Results are interpreted in a simplified model where each bottom squark is assumed to decay into the second-lightest neutralino χ 20 and a bottom quark, with χ 20 decaying into a Higgs boson and the lightest neutralino χ 10. The search focu…

PhysicsParticle physicsLarge Hadron Collider010308 nuclear & particles physicsPhysics beyond the Standard ModelHigh Energy Physics::Phenomenology01 natural sciencesBottom quarkStandard ModelPair production0103 physical sciencesNeutralinoHiggs bosonHigh Energy Physics::Experiment010306 general physicsLeptonPhysical Review D
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