0000000000519406

AUTHOR

Giuseppe D'agostino

showing 2 related works from this author

TRIC: an automated alignment strategy for reproducible protein quantification in targeted proteomics

2016

Nature Methods, 13 (9)

Pluripotent Stem CellsProteomics0301 basic medicineAnalyteStreptococcus pyogenesSoftware toolQuantitative proteomicsProteomic analysisComputational biologyBiologyProteome informaticsProteomicsBioinformaticsBiochemistryArticleMass Spectrometry03 medical and health sciencesSequence Analysis ProteinProtein methodsHumansProtein PrecursorsHuman Induced Pluripotent Stem CellsMolecular BiologyElectronic Data ProcessingReproducibility of ResultsCell BiologyMass spectrometricTargeted proteomics030104 developmental biologyProteolysissense organsPeptidesSequence AlignmentAlgorithmsSoftwareBiotechnologyNature Methods
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An APOE haplotype associated with decreased ε4 expression increases the risk of late onset Alzheimer's disease.

2011

This paper addresses a tenet of the literature on APOE, i.e., the relationship between the effects of the e4, one of the established genetic risk factor for Alzheimer's disease (AD), and its expression levels as determined by APOE promoter polymorphisms. Five polymorphisms (-491 rs449647, -427 rs769446, -219 rs405509, and e rs429358-rs7412) were studied in 1308 AD patients and 1082 control individuals from the Central-Northern Italy. Major findings of the present study are the following: 1) the variants -219T and e4 increase the risk for late onset AD (LOAD) when they are both present in cis on the same chromosome (in phase); 2) the correlation between the haplotype (-219T/e4) and AD risk p…

Apolipoprotein EMaleLinkage disequilibriumGENETICSApolipoprotein E4Late onsetGenome-wide association studyBiologyPolymorphism Single NucleotideLinkage DisequilibriumAlzheimer DiseaseRisk FactorsmedicineHumansGenetic Predisposition to DiseaseLongitudinal StudiesAlleleGeneticsChi-Square DistributionGeneral NeuroscienceHaplotypeAge FactorsGeneral MedicineSingle Nucleotidemedicine.diseasePOLYMORPHISMPsychiatry and Mental healthClinical PsychologyHaplotypesItalyFemaleApolipoprotein EGeriatrics and GerontologyAlzheimer's diseaseAge of onsetGenome-Wide Association StudyJournal of Alzheimer's disease : JAD
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