0000000000522298
AUTHOR
Ralf Dittrich
Human neonatal responses to androstenone
Poster P327 session VII: Olfactory Psychophysics & Clinical Studies; Central Olfaction; Aims. Human newborns show equal attraction to the odors of amniotic. fluid (AF) and mothers’ colostrum [1]. As 5-a-androst-16-en-3-. one (An) has been found in both fluids [2, 3], we studied it as a. potential vector of this perinatal odor continuity and of neonatal. attraction to the smell of breast and milk [4]. Methods. Two studies. were run. 1) We recorded the behavior of 16 newborns (3 days) and. 26 adults exposed to a saturating water solution of An and to 3. reference odorants [butyric acid, B; vanilla, V; water, W]. 2) We videotaped. 26 newborns (3 days) being administered 7 stimuli: 4 dilution. …
Responsiveness of human neonates to the odor of 5alpha-androst-16-en-3-one: A behavioral paradox?
The odorous steroid 5alpha-androst-16-en-3-one (AND) occurs in numerous biological fluids in mammals, including man, where it is believed to play a chemocommunicative role. As AND was recently detected in milk and amniotic fluid, sensitivity and hedonic responses to this substance were assessed in human neonates. To this aim, respiration and facial expressions were recorded in 3-day-old newborns in response to aqueous solutions of AND, ranging from 500ng/mL to 0.5 fg/mL. Although analyses of respiratory rate did not lead to clear-cut results, the newborns changed their facial expressions at concentrations not detected by adults in a triangle test. Newborns displayed negative facial actions …
Do overlapping odor constituents explain undifferentiated neonatal attraction to amniotic fluid and human milk?
ISBN-10: 3-938896-38-9 ISBN-13: 978-3-938896-38-9; International audience
Identification of odor active substances in human amniotic fluid
Poster P326 session VII: Olfactory Psychophysics & Clinical Studies; Central Olfaction; Objectives. Physiological evidence indicates that olfaction could. already function in the human fetus [1]. Right after birth the odor. of amniotic fluid (AF) is detectable to newborns and seems to. attract [2] and calm them [3]. Such early attraction may derive. from fetal learning/memory, and may help newborns adapt to the. postnatal environment. The chemosensory basis of AF. attractiveness has not been investigated yet, and this study aimed. to characterize odor active compounds therein. Methods. The. flavor profile of AF was monitored by descriptive sensory. evaluation using an adult panel, while the…
Gonadal damage and options for fertility preservation in female and male cancer survivors.
It is estimated that in 2010, 1 in every 250 adults will be a childhood cancer survivor. Today, oncological surgery, radiotherapy and chemotherapy achieve relatively high rates of remission and long-term survival, yet are often detrimental to fertility. Quality of life is increasingly important to long-term survivors of cancer, and one of the major quality-of-life issues is the ability to produce and raise normal children. Developments in the near future in the emerging field of fertility preservation in cancer survivors promise to be very exciting. This article reviews the published literature, discusses the effects of cancer treatment on fertility and presents the options available today …
Human sweat odour conjugates in human milk, colostrum and amniotic fluid
International audience; Using ultra performance liquid chromatography-mass spectrometry we identified for the first time glutamine-N-alpha-conjugates of the fatty acids (E)/(Z)-3-methylhex-2-enoic acid and (R)/(S)-3-hydroxy-3-methylhexanoic acid as well as cysteinylglycine-S-conjugates of (R)/(S)-3-methyl-3-sulphanylhexan-1-ol and (R)/(S)-3-sulphanylhexan-1-ol as constituents of human milk and colostrum. The glutamine-N-alpha-conjugates were detected also in human amniotic fluids. The mean values of glutamine-N-alpha-conjugate of (R)/(S)-3-hydroxy-3-methylhexanoic acid were highest in colostrums with a range of <0.1-382 mu g/kg, followed by the mature human milk with values from <0.1 to 39.…
Pretreatment with gonadotropin-releasing hormone (GnRH) antagonists to prevent the flare-up effect of long-acting GnRH agonists: results of a pilot study.
This study evaluated in vivo whether the flare-up effect of GnRH agonists can be suppressed through pretreatment with a GnRH antagonist. The classic flare-up effect caused by 3.8 mg goserelin acetate could not be suppressed through pretreatment using a single dosage of 3.24 mg cetrorelix acetate.
Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection
Item does not contain fulltext Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We performed genome-wide association studies (GWAS) in 1,393 CeAD cases and 14,416 controls. The rs9349379[G] allele (PHACTR1) was associated with lower CeAD risk (odds ratio…
Reproduction beyond cancer: A message of hope for young women
Abstract Objective. Aggressive chemotherapy and radiotherapy or radical oncological surgery in young women with cancer has greatly enhanced these patients' life expectancy, but these treatments often cause infertility or premature ovarian failure due to a massive destruction of the ovarian reserve. The objective of this review is to discuss the effect of the various cancer treatments on fertility and present the various fertility sparing operations and fertility preservation strategies. Method. An extensive survey of the most up-to-date literature was performed. Results. This review discusses the impact of current cancer treatment on fertility potential and the various surgical and assisted…
Unconditional response to offensive smells: what we learn from newborns'reactions
Years after years, the accumulation of results permits us to better. understand the development of human food preferences during the. lifespan. The foetal and neonatal periods appear to be very important. in this process. Neonates are attracted to volatile compounds. being present in the amniotic environment (Marlier et al., 1997). Women who consumed garlic, alcohol, anise, or carrot flavour in. late pregnancy produce offsprings that manifest positive responses. towards these odorants, for durations ranging from hours, days to. months (Hepper, 1995; Faas et al., 2000; Schaal et al., 2000; Mennella. et al., 2001). After birth, the exposition to an artificial odorant. (camomile) spread on the…
The extracorporeal perfusion of the female pig detrusor as an experimental model for the study of bladder contractility.
Aims The objective of the study was to establish an experimental model for the extracorporeal perfusion of the pig detrusor. In order to validate this model we examined some biochemical parameters and determined the effect of carbachol on the contractility of perfused female pig bladders. Methods Twenty-six pig bladders were perfused with Krebs–Ringer bicarbonate-glucose buffer for a period up to 5 hr with the aim to preserve a viable organ, which would be responsive to contraction-inducing agents. The intravesical pressure of the bladder as well as the intraarterial pressure of the vesical arteries were recorded before and after administration of carbachol. Results The perfusate pH, lactat…
The effect of cancer treatment on female fertility and strategies for preserving fertility.
Aggressive chemotherapy and radiotherapy in young patients with cancer has greatly enhanced the life expectancy of these patients, but these treatments often cause infertility because of the massive destruction of the ovarian reserve resulting in premature ovarian failure (POF). This review focuses on the effect of cancer treatments on fertility and on the various surgical and assisted-reproduction innovations that are available to provide the patient with the option of future pregnancies. As the emerging discipline of fertility preservation is steadily attracting increasing interest, developments in the near future promise to be very exciting. However, in everyday routine work, better inte…
Fertility protection: complications of surgery and results of removal and transplantation of ovarian tissue
Fertility-preserving measures are becoming important for patients receiving oncological treatment. One method involves cryopreservation of ovarian tissue and transplanting it when treatment is completed. We report complications resulting from surgical and fertility medicine, and the results of procedures for the removal and transplantation of ovarian tissue carried out within the FertiProtekt network. A survey using a structured questionnaire was conducted among the FertiProtekt network centres between November 2015 and June 2016. The analysis included surgical techniques used to remove and transplant ovarian tissue, surgical complications and results. Laparoscopic removal and transplantati…