0000000000527654
AUTHOR
Daniel Raederstorff
Dietary n-3 PUFAs affect the blood pressure rise and the cardiac function modulation in a hyperinsulinemia rat model in vivo
National audience; This study was designed to assess in vivo the cardiovascular consequences of a dietary docosahexaenoic (DHA) or eicosapentaenoic (EPA) acid specific intake in a hyperinsulinemia (HI) model presented by fructose-induced insulin-resistant rats. Wistar rat (n=6 in each dietary group of control or HI rats) were fed for two months a diet containing 62% fructose, and supplemented (or not for control, NFD) with either DHA or EPA (240 mg per day). Modifications of the cardiovascular parameters (rise in blood pressure (BP), heart rate (HR), modulation, ECG) were continously monitored using an intra-abdominal implanted telemetry system in HI rats. The myocardial phospolipid fatty a…
Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo
International audience; This study was designed to evaluate the effects of individual dietary long-chain n-3 polyunsaturated fatty acids (LCPUFA) on hypertension and cardiac consecutive disorders in spontaneously hypertensive rats (SHR) as compared to Wistar-Kyoto rats (WKY). Rats were fed for 2 months an eicosapentaenoic (EPA)- or docosahexaenoic acid (DHA)-rich diet (240 mg/day) or an n-3 PUFA-free diet. Male SHR (n=6), implanted with cardiovascular telemetry devices, were housed in individual cages for continuous measurements of cardiovascular parameters (blood pressure (BP) and heart rate (HR)) during either activity or rest periods, ECG were recorded during the quiet period. The n-6 PU…
Influence du DHA alimentaire sur les fonctions cardiovasculaires chez le rat SHR in vivo
National audience
Influence du DHA alimentaire sur la fonction cardiovasculaire chez le rat SHR in vivo
National audience