0000000000527841
AUTHOR
Erika Roman
Behavioral Profiling in Early Adolescence and Early Adulthood of Male Wistar Rats After Short and Prolonged Maternal Separation
Early-life stress and its possible correlations to genes, environment, and later health outcomes can only be studied retrospectively in humans. Animal models enable the exploration of such connections with prospective, well-controlled study designs. However, with the recent awareness of replicability issues in preclinical research, the reproducibility of results from animal models has been highlighted. The present study aims to reproduce the behavioral effects of maternal separation (MS) previously observed in the multivariate concentric square fieldTM (MCSF) test. A second objective was to replicate the adolescent behavioral profiles previously described in the MCSF test. Male rats, subjec…
Neuronal and neuroendocrine mechanisms of social rank and stress coping in teleost fish
Fights for social dominance are stressful and results in an activation of the brain serotonergic system. Subordinate animals in an established dominance hierarchy are characterized by a chronic elevation of brain serotonergic activity, an effect that seems to mediate the behavioural inhibition observed in these animals. By contrast, social dominance has been associated with elevated dopaminergic activity, and dopamine (DA) has behavioural effects to some extent opposing those of serotonin (5HT). In addition to effects of the social environment, brain monoaminergic functions are controlled by genetic factors. For instance, zebrafish (Danio rerio) classified as bold, showing a propensity for …