0000000000529646

AUTHOR

Gunter Mayer

showing 3 related works from this author

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

2009

T helper cells secreting interleukin (IL)-17 (Th17 cells) play a crucial role in autoimmune diseases like multiple sclerosis (MS). Th17 differentiation, which is induced by a combination of transforming growth factor (TGF)-beta/IL-6 or IL-21, requires expression of the transcription factor retinoic acid receptor-related orphan receptor gamma t (ROR gamma t). We identify the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) as a key negative regulator of human and mouse Th17 differentiation. PPAR gamma activation in CD4(+) T cells selectively suppressed Th17 differentiation, but not differentiation into Th1, Th2, or regulatory T cells. Control of Th17 differentia…

MESH: Nuclear Receptor Subfamily 1 Group F Member 3Helper-InducerReceptors Retinoic AcidT-LymphocytesMESH: Interleukin-17Cellular differentiationRetinoic AcidPeroxisome proliferator-activated receptorNeurodegenerativeInbred C57BLMedical and Health SciencesMiceInterleukin 210302 clinical medicineGroup FRAR-related orphan receptor gammaMESH: Nuclear Receptor Co-Repressor 2Receptors2.1 Biological and endogenous factorsThyroid HormoneImmunology and AllergyMESH: AnimalsAetiologyEncephalomyelitisPromoter Regions Geneticchemistry.chemical_classificationOrphan receptor0303 health sciencesReceptors Thyroid HormoneInterleukin-17Cell DifferentiationT-Lymphocytes Helper-InducerNuclear Receptor Subfamily 1 Group F Member 33. Good healthCell biologyDNA-Binding Proteinsmedicine.anatomical_structureMESH: Repressor Proteins[SDV.IMM]Life Sciences [q-bio]/ImmunologyInterleukin 17MESH: Cell Differentiationmedicine.medical_specialtyEncephalomyelitis Autoimmune ExperimentalMultiple SclerosisNuclear Receptor Subfamily 1Member 31.1 Normal biological development and functioningT cellImmunologyBiologyAutoimmune DiseasePromoter RegionsExperimental03 medical and health sciencesGeneticUnderpinning researchMESH: Mice Inbred C57BLInternal medicineMESH: Promoter Regions GeneticGeneticsmedicineAnimalsHumansNuclear Receptor Co-Repressor 2MESH: Receptors Thyroid HormoneMESH: T-Lymphocytes Helper-InducerMESH: Encephalomyelitis Autoimmune ExperimentalMESH: Mice030304 developmental biologyMESH: Receptors Retinoic AcidMESH: HumansInflammatory and immune systemNeurosciencesBrief Definitive ReportCorrectionMESH: Multiple SclerosisBrain DisordersMice Inbred C57BLPPAR gammaRepressor ProteinsEndocrinologyMESH: PPAR gammaNuclear receptorchemistryMESH: DNA-Binding Proteins030217 neurology & neurosurgeryAutoimmuneJournal of Experimental Medicine
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Modellbetrachtung zur Radikalausbeute bei der radikalischen Polymerisation

1974

Die kinetisch wirksame Radikalausbeute ist eine chemisch und diffusionskontrollierte Grose. Der Grad der jeweiligen Kontrolle ist systemspezifisch. Die chemische Kontrolle geht hauptsachlich von der Kettenstartreaktion, die Diffusionskontrolle von der Primarradikalrekombination aus. Die entwickelte Modellvorstellung erfast diese konkurrierenden Einflusse. Mittlere Diffusionswege der Primarradikale bis zu ihrer Rekombination werden abgeschatzt. The kinetically effective radical efficiency is chemically and diffusion controlled. The proportion of each control mechanism characterizes the polymerizing system. The chemical control can be deduced from the chain initiation reaction, the diffusion …

ChemistryRadicalPolymer chemistryChemical controlDie Makromolekulare Chemie
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Über die Elementarreaktionen der radikalischen Polymerisation von Benzylmethacrylat

1973

Durch Kombination stationarer und instationarer Methodik (rotierender Sektor) werden die Absolutwerte der Geschwindigkeitskonstanten von Kettenwachstum und Kettenabbruch von Benzylmethacrylat unter dem Einflus verschieden viskoser Losungsmittel bestimmt. Die Radikalausbeute f hangt von der Viskositat des Losungssystems und der Art der Monomeren, dagegen nicht (oder fast nicht) von der Konzentration des Monomeren und der Geschwindigkeit der Radikalerzeugung ab. Daraus wird geschlossen, das ein merklicher Anteil von Zwillingsrekombinationen auserhalb des primaren Losungsmittelkafigs stattfindet. Die Geschwindigkeitskonstante kw des Kettenwachstums stimmt praktisch uberein mit der des Methylme…

Solvent systemPolymers and PlasticsChemistryAbsolute rateChain terminationInternal viscositySolventchemistry.chemical_compoundViscosityColloid and Surface ChemistryMonomerReaction rate constantPolymer chemistryMaterials ChemistryPhysical and Theoretical ChemistryMethyl methacrylateColloid and Polymer Science
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