0000000000530248

AUTHOR

Hans Grosse-wilde

showing 4 related works from this author

Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man.

1976

The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygousdeficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HLA-A,B antigens, HLA-D (MLC) determinants; the Bf system; glyoxalase I and B cell antigens. No evidence for linkage between the immunogenetic linkage group on chromosome 6 and gene(s) controlling the synthesis of the seventh component of complement was obtained. This is in accordance with the assumption that only genes controlling components of the initiating rather than the membrane attack unit of…

GeneticsChromosomes Human 6-12 and XMaleGenetic LinkageChromosomeHuman leukocyte antigenComplement System ProteinsBiologyComplement factor BHuman geneticsComplement C7Complement (complexity)medicine.anatomical_structureAntigenHLA AntigensHistocompatibility AntigensGeneticsmedicineHumansLymphocyte Culture Test MixedChildGeneGenetics (clinical)B cellHuman genetics
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Detection of Anti-MICA Antibodies in Patients Awaiting Kidney Transplantation, during the Post-transplant Course, and in Eluates from Rejected Kidney…

2005

Previously we have reported on the development of antibodies against MICA alleles in kidney transplant recipients. These alloantibodies have now been determined using a new assay using Luminex beads bound to soluble recombinant MICA antigens produced in insect cells. In the present study we have analyzed sera from 85 kidney transplant recipients on the waiting list and 66 patients transplanted within the last 4 years and 59 acid eluates obtained from allograft nephrectomy specimens. Many of the patients in those groups were sensitized and some had previous transplants (waiting list: 15%; post-tx: 7.6%; eluates 22%) and their sera were found to contain anti-human leukocyte antigen (HLA) and …

AdultGraft RejectionMaleImmunologyHuman leukocyte antigenPathogenesisAntigenIsoantibodiesmedicineHumansImmunology and AllergyKidney transplantationKidneybiologyHistocompatibility Antigens Class IGeneral MedicineFlow Cytometrymedicine.diseaseKidney TransplantationRecombinant ProteinsTransplant rejectionstomatognathic diseasesmedicine.anatomical_structureImmunizationLuminescent MeasurementsImmunologybiology.proteinFemaleAntibodyHuman Immunology
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Antigens of the major histocompatibility complex in patients with chronic discoid lupus erythematosus.

1990

summary The frequencies of the major histocompatability complex class I, class II and class III antigens were determined in 130 patients (88 women and 42 men) with chronic discoid lupus erythematosus, and compared with those of 764 healthy controls. A significant increase in HLA-B7 (38.0% in the patients vs. 25·8% in the control group), HLA-B8 (29·5% vs. 17·4%), HLA-Cw7 (58·9% vs. 26·1%), HLA-DR2 (46·9% vs. 29·7%), HLA-DR3 (32·0% vs. 19·4%), HLA-DQwi (76·6% vs. 60·5%), and a decrease in HLA-A2 (41·9% vs. 55·7%) was found. The calculated relative risk values for the respective antigens markedly increased when two or more antigens were present in one patient, with a maximum relative risk valu…

MaleRiskmedicine.medical_specialtySystemic diseaseDermatologyHLA-C AntigensMajor histocompatibility complexGastroenterologyHLA-B8 AntigenHLA-B7 AntigenHLA-DR3 AntigenLupus Erythematosus DiscoidAntigenHLA AntigensInternal medicineHLA-DQ AntigensHLA-A2 AntigenmedicineHumansIn patientHLA-DR2 AntigenLupus erythematosusbiologybusiness.industrymedicine.diseaseConnective tissue diseaseRelative riskImmunologyChronic Diseasebiology.proteinFemaleDisease SusceptibilitybusinessChronic discoid lupus erythematosusThe British journal of dermatology
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14th International HLA and Immunogenetics Workshop: Report on the Prospective Chronic Rejection Project

2007

An international collaborative study of 45 transplant centers was undertaken at the 14th International HLA (human leukocyte antigen) and Immunogenetics Workshop to see if HLA antibodies detected posttransplant are predictive of chronic graft failure. With the newly developed assay, MICA (major histocompatibility complex class I-related chain A) antibodies were also measured and their effect analyzed. Total of 5219 sera from patients who were more than 6 months posttransplant with functioning graft were tested for HLA antibodies by enzyme-linked immunosorbent assay, flow cytometry, or Luminex. HLA antibodies were found in 27.2% of kidney patients, 23.6% in the liver, 52.7% in the heart, and …

Graft RejectionMICA antibodyImmunologyHuman leukocyte antigenHistocompatibility TestingImmunogeneticsMajor histocompatibility complexBiochemistryimmunogenetics workshopchronic rejectionHLA AntigensTransplantation ImmunologyImmunogeneticsGeneticsmedicineHumansImmunology and AllergyHLA antibodyKidneyLungbiologybusiness.industryHistocompatibility TestingGraft SurvivalHistocompatibility Antigens Class IPanel reactive antibodymulti-center studyGeneral MedicineKidney Transplantationmedicine.anatomical_structureChronic DiseaseImmunologybiology.proteinHeart TransplantationAntibodybusinessTissue Antigens
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