6533b838fe1ef96bd12a48de
RESEARCH PRODUCT
Antigens of the major histocompatibility complex in patients with chronic discoid lupus erythematosus.
Gisela BonsmannP. KindGünter GoerzGabriele DoxiadisIlias I.n. DoxiadisJ. KnopU. VögelerHans Grosse-wildesubject
MaleRiskmedicine.medical_specialtySystemic diseaseDermatologyHLA-C AntigensMajor histocompatibility complexGastroenterologyHLA-B8 AntigenHLA-B7 AntigenHLA-DR3 AntigenLupus Erythematosus DiscoidAntigenHLA AntigensInternal medicineHLA-DQ AntigensHLA-A2 AntigenmedicineHumansIn patientHLA-DR2 AntigenLupus erythematosusbiologybusiness.industrymedicine.diseaseConnective tissue diseaseRelative riskImmunologyChronic Diseasebiology.proteinFemaleDisease SusceptibilitybusinessChronic discoid lupus erythematosusdescription
summary The frequencies of the major histocompatability complex class I, class II and class III antigens were determined in 130 patients (88 women and 42 men) with chronic discoid lupus erythematosus, and compared with those of 764 healthy controls. A significant increase in HLA-B7 (38.0% in the patients vs. 25·8% in the control group), HLA-B8 (29·5% vs. 17·4%), HLA-Cw7 (58·9% vs. 26·1%), HLA-DR2 (46·9% vs. 29·7%), HLA-DR3 (32·0% vs. 19·4%), HLA-DQwi (76·6% vs. 60·5%), and a decrease in HLA-A2 (41·9% vs. 55·7%) was found. The calculated relative risk values for the respective antigens markedly increased when two or more antigens were present in one patient, with a maximum relative risk value of 7·4 for the combinations of HLA-Cw7, DR3, DQwi and HLA-B7, Cw7 and DR3, which were found in 17·2% of the patients and in only 2·3% of the controls.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1990-06-01 | The British journal of dermatology |