0000000000530330

AUTHOR

S. Barkia Beradhi

showing 1 related works from this author

HLA Class II Differentiates Between Thyroid and Polyglandular Autoimmunity.

2015

The HLA class II genes are susceptibility genes for autoimmune endocrine diseases; however, scarce data are available pertaining to the determinants of genetic susceptibility to polyglandular autoimmunity (PGA). A total of 300 consecutive and unselected patients with either PGA or monoglandular autoimmune thyroid disease (AITD) and 100 healthy control subjects were genotyped for the HLA class II DRB1, -DQA1, and -DQB1 alleles. Compared to patients with AITD and controls, the HLA-DRB1*03 (pc =0.001), *04 (pc<0.001), -DQA1*03 (pc<0.001), and -DQB1*02 (pc =0.001) alleles were increased in patients with PGA. When dividing patients with Hashimoto's thyroiditis (HT) into those with PGA (PGA-HT) v…

musculoskeletal diseasesAdultMalemedicine.medical_specialtyendocrine system diseasesAdolescentEndocrinology Diabetes and MetabolismGraves' diseaseClinical BiochemistryThyroid GlandAutoimmunityImmunogeneticsHashimoto Diseasemedicine.disease_causeBiochemistryThyroiditisAutoimmunityYoung AdultEndocrinologyInternal medicineGenetic predispositionMedicineHumansHashimoto DiseaseGenetic Predisposition to DiseaseAlleleskin and connective tissue diseasesChildbusiness.industryBiochemistry (medical)ThyroidHistocompatibility Antigens Class IIInfantGeneral MedicineMiddle Agedmedicine.diseaseGraves DiseaseEndocrinologymedicine.anatomical_structureChild PreschoolImmunologyFemalebusinessHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
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