0000000000531542
AUTHOR
Juan Jose Perez-ruixo
Dosage individualization of erythropoietin using a profile-dependent support vector regression
The external administration of recombinant human erythropoietin is the chosen treatment for those patients with secondary anemia due to chronic renal failure in periodic hemodialysis. The objective of this paper is to carry out an individualized prediction of the EPO dosage to be administered to those patients. The high cost of this medication, its side-effects and the phenomenon of potential resistance which some individuals suffer all justify the need for a model which is capable of optimizing dosage individualization. A group of 110 patients and several patient factors were used to develop the models. The support vector regressor (SVR) is benchmarked with the classical multilayer percept…
Multi-dimensional Function Approximation and Regression Estimation
In this communication, we generalize the Support Vector Machines (SVM) for regression estimation and function approximation to multi-dimensional problems. We propose a multi-dimensional Support Vector Regressor (MSVR) that uses a cost function with a hyperspherical insensitive zone, capable of obtaining better predictions than using an SVM independently for each dimension. The resolution of the MSVR is achieved by an iterative procedure over the Karush-Kuhn-Tucker conditions. The proposed algorithm is illustrated by computers experiments.
Therapeutic Drug Monitoring of Kidney Transplant Recipients Using Profiled Support Vector Machines
This paper proposes a twofold approach for therapeutic drug monitoring (TDM) of kidney recipients using support vector machines (SVMs), for both predicting and detecting Cyclosporine A (CyA) blood concentrations. The final goal is to build useful, robust, and ultimately understandable models for individualizing the dosage of CyA. We compare SVMs with several neural network models, such as the multilayer perceptron (MLP), the Elman recurrent network, finite/infinite impulse response networks, and neural network ARMAX approaches. In addition, we present a profile-dependent SVM (PD-SVM), which incorporates a priori knowledge in both tasks. Models are compared numerically, statistically, and in…
Population pharmacokinetics of 5-fluorouracil in colorectal cancer patients
Aims. The pharmacokinetics of 5-fluorouracil (5-FU) after intravenous administration in color- ectal cancer patients were examined using population analysis. The relevant covariates and the extent of inter- and intraindividual variability were evaluated. Methods. Data from 27 patients with diagnosis of nonmetastatic colorectal adenocarcinoma receiving weekly 5-FU (450 mg/m2), plus levamisol 50 mg/8 hours by oral route for 3 days every 15 days, were pooled with data from 17 patients with diagnosis of metastatic colorectal adenocarcinoma, receiving daily 5-FU (425 mg/m2) and intravenous folinic acid (20 mg/m2) over five consecutive days (daily times five), every four weeks. In both groups 5-…