0000000000536359
AUTHOR
M. Ferrari
Il substrato dentinale lungo il post-space prima della cementazione adesiva dei perni in fibra
Obiettivi: nel seguente lavoro è stata valutata la morfologia delle superfici dentinali lungo il post-space, subito prima delle fasi connesse con la cementazione adesiva, per verificare le modificazioni indotte dalle procedure che "routinariamente" si effettuano per renderlo idoneo all'adesione di un perno in fibra, durante la preparazione meccanica del post-space ed il condizionamento del sub strato dentinale. Metodi: su 20 elementi dentali monoradicolati, estratti e divisi in 2 gruppi trattati endodonticamente con strumenti in NiTi e con due diversi protocolli di irrigazione , sono stati preparati , con frese calibrate gli alloggiamenti per il perno in fibra. Le superfici lungo il post sp…
CHARACTERIZATION OF THE GAMMA DOSE COMPONENT IN THE NEUTRON FIELD OF A BNCT IRRADIATION FACILITY
At the University of Pavia, a neutron irradiation facility has been constructed for preclinical in vitro and in vivo studies for BNCT. The facility is a wide channel (40 x 20 x 100 cm3) inside the graphite Thermal Column of the 250 KW research reactor TRIGA Mark II. The neutron field consists in a thermal component ranging from about 1010 and 109 cm-2s-1 along the longitudinal axis of the channel and it is uniform within 10% along the transversal axes. The fast neutron contamination (En > 1.58 keV) is more than 2 orders of magnitude lower. The gamma background coming from the core has been reduced with a 20 cm thick bismuth shield, however in the facility a gamma component is still prese…
Consensus protocol for EEG and amplitude-integrated EEG assessment and monitoring in neonates
The aim of this work is to establish inclusive guidelines on electroencephalography (EEG) applicable to all neonatal intensive care units (NICUs). Guidelines on ideal EEG monitoring for neonates are available, but there are significant barriers to their implementation in many centres around the world. These includebarriers due to limited resources regarding the availability of equipment and technical and interpretive round-the-clock personnel. On the other hand, despite its limitations, amplitude-integrated EEG (aEEG) (previously called Cerebral Function Monitor [CFM]) is a common alternative used in NICUs.The Italian Neonatal Seizure Collaborative Network (INNESCO), working with all nation…
Quality controls for cell cultures: identification of interspecies cross-contamination by PCR-RFLP analysis of the cytochrome b gene
Cross-contaminations of a cell line with cells of different species represent a potential risk in laboratories handling human and animal cells. Therefore, it is necessary to control such contaminations. Tests based on mitochondrial DNA (mtDNA) are used in forensic analysis, phylogenetic studies and in food authentication. However, the use of mtDNA in quality controls of cell cultures is recent. Mitochondrial sequence differences of closely related animal species are five- to tenfold higher than those of nuclear genes. On the contrary, intraspecies variation in mitochondrial sequences is low in most animal species. Moreover, each cell contains 100–10.000 mitochondrial genomes. The amount of …
Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010
The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2…
Neutron flux and gamma dose measurement in the BNCT irradiation facility at the TRIGA reactor of the University of Pavia
Abstract University of Pavia is equipped with a TRIGA Mark II research nuclear reactor, operating at a maximum steady state power of 250 kW. It has been used for many years to support Boron Neutron Capture Therapy (BNCT) research. An irradiation facility was constructed inside the thermal column of the reactor to produce a sufficient thermal neutron flux with low epithermal and fast neutron components, and low gamma dose. In this irradiation position, the liver of two patients affected by hepatic metastases from colon carcinoma were irradiated after borated drug administration. The facility is currently used for cell cultures and small animal irradiation. Measurements campaigns have been ca…
Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes
Background Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici D…
SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…
Caratterizzazione dosimetrica della facility a neutroni termici del reattore TRIGA di Pavia: studio della dose da fotoni mediante rivelatori ESR di alanina
The optimization of the procedures of Neutron Capture Therapy (NCT) for cancer treatments involves research for beam characterization. One major issue for this therapy is the reliable dosimetric determination of the various (neutronic and photonic) components of the employed beam. In particular, the precise and accurate measurements of the gamma photon component is fundamental for evaluating the risks to healthy tissues hit by the mixed field. Among solid state dosimeters the alanine detectors read by Electron Paramagnetic Resonance (EPR) technique present several advantages such as: tissue equivalence for photon and electron beams, linearity of its dose-response over a wide range, high sta…
Determinazione della componente gamma nella colone termica del reattore TRIGA di Pavia tramite Dosimetri ESR di alanina
Negli ultimi anni il crescente interesse verso la radioterapia a cattura neutronica (internazionalmente nota come Neutron Capture Therapy - NCT) per il trattamento di neoplasie ha stimolato diverse attività di ricerca finalizzate alla caratterizzazione del fascio utilizzato e all'ottimizzazione delle procedure radioterapiche. Tra i vari sistemi dosimetrici trovano largo impiego i rivelatori a stato solido ESR (Risonanza di Spin Elettronico) a base di alanina che presentano diversi vantaggi come la tessuto equivalenza, la linearità della risposta in un ampio intervallo di dose, l'elevata stabilità dei radicali liberi radioindotti, la non distruttività della lettura del dosimetro e il basso c…