Effetti benefici degli oli essenziali nel trattamento anti-obesità

Pain in paediatric hospital units

p8 (candidate of metasiasis 1) drives ER-stress/autophagy/apoptosis axis induced by the synthetic cannabinoid WIN in HCC cells.

Background: Today, evidence is emerging for the role of autophagy in the regulation of life and death of tumour cells and its relationship with ER-stress signaling. Our previous results demonstrated that hepatoma HepG2 cells are sensitive to apoptotic effects induced by WIN, a synthetic cannabinoid, which acts through a mechanism involving the reduction in the levels of some survival factors and the activation of pro-apoptotic ones. Since WIN effects were observed after 36−48 hours of treatment, we investigated the possible activation of ER-stress and autophagic process in the first hours of WIN treatment focusing our attention on p8, a factor whose expression is upregulated in response to …

Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes

Background Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage ≥3 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage ≥3 CKD in a large cohort of patients affected by T1DM. Methods A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici D…

Let-7d-5p miRNA shows oncogenic functions in triple negative breast cancer

Triple negative breast cancer (TNBC) is a highly aggressive subtype of BC which lack of targeted therapies and is associated with poor prognosis. The presence of Cancer Stem Cells (CSCs) could be responsible for TNBC resistance to therapy, recurrence and metastasis, and might explain the difficult of its eradication. MiRNAs -a class of small non-coding RNAs- can modulate gene expression and their dysregulation may cause cancer formation. The let-7 family is dysregulated in various cancers and often its roles are unclear and of difficult interpretation. For example, let-7d can be over- or down-expressed and can act as tumor suppressor or oncogene. Here, we evaluated the expression profiles o…

Different modulatory effect of the synthetic cannabinoid WIN55,212-2 on tumor cell migration.

MicroRNAs are small non-coding regulatory molecules exerting pleiotropic action in different biological processes such as proliferation, differentiation, apoptosis, migration and metastasis. Deregulation of miRNA expression has been observed in various cancers, and accumulating data suggest that miRNAs can display an oncogenic, antioncogenic or an ambiguous behavior in relationship to tumor environment. In a previous research we showed that the synthetic cannabinoid WIN55,212-2 is able to reduce the migratory activity of osteosarcoma MG63 cells analyzed by means of wound healing assay. So we undertook a study to evaluate the biochemical mechanism through which WIN plays this action. To this…

Ethanol promotes survival and tumor progression of colon cancer cells

In the Western Countries, colon cancer is the third tumor for aggressiveness and incidence after lung and breast/prostate cancer. Different risk factors concur to the development of colon cancer, including genetic factors, inflammation, intestinal microflora composition, as well as lifestyle. Epidemiologic studies correlating alcohol consumption and assert that the risks are 5-fold higher among drinkers compared to nondrinkers. However, the exact mechanisms correlating heavy alcohol drinking and colon cancer are not completely elucidated yet. To shed light on the biochemical mechanisms through which alcohol favors colon cancer progression, we evaluated the effect of high doses of ethanol (1…

Il sostegno e il miglioramento delle coltivazioni sub-tropicali in Sicilia traggono vantaggio dallo studio e dalla promozione delle loro proprietà nutrizionali.

Negli ultimi decenni si è assistito a un continuo progresso scientifico in ambito nutrizionale che ha trovato le sue basi da una parte nella scoperta dei principi nutritivi contenuti negli alimenti e dall'altra nell'elaborazione di precise linee guida a larga diffusione. Un'inadeguata alimentazione, infatti, oltre a incidere sul benessere psicofisico, rappresenta uno dei principali fattori di rischio per l'insorgenza di numerose patologie croniche. Secondo l'Organizzazione Mondiale della Sanità (OMS) il rischio di insorgenza di malattie cardiovascolari, metaboliche e di alcuni tumori si abbassa considerevolmente grazie a una corretta e sana alimentazione.

TUMORI MALIGNI RARI NEL BAMBINO: DATI DA UNO STUDIO RETROSPETTIVO MULTICENTRICO

Le neoplasie con incidenza annuale inferiore a 2 casi per milione di bambini sono considerate rare. Allo scopo di valutare l'esperienza dei pricipali Centri pediatrici e chirurgici-pediatrici su tumori maligni rari attualmente non registrati in protocolli nazionali, è stato condotto uno studio retrospettivo cooperativo. Sono stati registrati 164 pazienti osservati in 34 Centri Italiani dal 1982 al 1993.