0000000000537378

AUTHOR

Samuel Hernández

showing 4 related works from this author

Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical…

2022

BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperati…

AdultLung Diseases*PEEP*postoperative pulmonary complicationsmechanical ventilationPositive-Pressure RespirationsurgeryAnesthesiology and Pain MedicinePostoperative ComplicationsTidal Volume*surgeryHumanspostoperative pulmonary complicationsPostoperative Period*mechanical ventilationmechanical ventilation; PEEP; postoperative pulmonary complications; surgery; Adult; Humans; Lung; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Tidal Volume; Lung Diseases; Positive-Pressure RespirationLungPEEPRandomized Controlled Trials as Topic
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Individualised perioperative open-lung approach versus standard protective ventilation in abdominal surgery (iPROVE): a randomised controlled trial

2018

Background The effects of individualised perioperative lung-protective ventilation (based on the open-lung approach [OLA]) on postoperative complications is unknown. We aimed to investigate the effects of intraoperative and postoperative ventilatory management in patients scheduled for abdominal surgery, compared with standard protective ventilation. Methods We did this prospective, multicentre, randomised controlled trial in 21 teaching hospitals in Spain. We enrolled patients who were aged 18 years or older, were scheduled to have abdominal surgery with an expected time of longer than 2 h, had intermediate-to-high-risk of developing postoperative pulmonary complications, and who had a bod…

MalePulmonary and Respiratory Medicinemedicine.medical_treatmentPopulationPerioperative Carelaw.inventionPositive-Pressure Respiration03 medical and health sciencesPostoperative Complications0302 clinical medicineRandomized controlled trial030202 anesthesiologylawOxygen therapyAbdomenmedicineHumansProspective Studies030212 general & internal medicineContinuous positive airway pressureeducationLungAgedMechanical ventilationeducation.field_of_studybusiness.industryPerioperativeMiddle AgedRespiration Artificialrespiratory tract diseasesTreatment OutcomeSpainAnesthesiaBreathingFemalebusinessAbdominal surgery
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Altered expression of neuropeptides in the primary somatosensory cortex of the Down syndrome model Ts65Dn.

2011

Down syndrome is the most common genetic disorder associated with mental retardation. Subjects and mice models for Down syndrome (such as Ts65Dn) show defects in the formation of neuronal networks in both the hippocampus and the cerebral cortex. The principal neurons display alterations in the morphology, density and distribution of dendritic spines in the cortex as well as in the hippocampus. Several evidences point to the possibility that the atrophy observed in principal neurons could be mediated by changes in their inhibitory inputs and, in fact, an imbalance between excitation and inhibition has been observed in Ts65Dn mice in these regions, which are crucial for learning and informati…

Malemedicine.medical_specialtyDendritic spineHippocampusBiologySomatosensory systemCalbindinHippocampusCellular and Molecular NeuroscienceMiceEndocrinologyInterneuronsCortex (anatomy)Internal medicinemedicineAnimalsNeuronsEndocrine and Autonomic SystemsCalcium-Binding ProteinsNeuropeptidesGeneral MedicineSomatosensory CortexDisease Models Animalmedicine.anatomical_structureEndocrinologySomatostatinnervous systemNeurologyCerebral cortexCalretininDown SyndromeSomatostatinNeuroscienceNeuropeptides
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The Polysialylated Form of the Neural Cell Adhesion Molecule (PSA-NCAM) Is Expressed in a Subpopulation of Mature Cortical Interneurons Characterized…

2010

Principal neurons in the adult cerebral cortex undergo synaptic, dendritic, and spine remodeling in response to different stimuli, and several reports have demonstrated that the polysialylated form of the neural cell adhesion molecule (PSA-NCAM) participates in these plastic processes. However, there is only limited information on the expression of this molecule on interneurons and on its role in the structural plasticity of these cells. We have found that PSA-NCAM is expressed in mature interneurons widely distributed in all the extension of the cerebral cortex and have excluded the expression of this molecule in most principal cells. Although PSA-NCAM expression is generally considered a …

MaleNeurogenesisCognitive NeuroscienceCellular differentiationNeural InhibitionNeural Cell Adhesion Molecule L1BiologyInhibitory postsynaptic potentialRats Sprague-DawleyCellular and Molecular NeuroscienceInterneuronsNeural PathwaysNeuroplasticitymedicineAnimalsCell ShapeCerebral CortexNeuronal PlasticityEmbryogenesisNeurogenesisCell DifferentiationNeural InhibitionRatsmedicine.anatomical_structurenervous systemCerebral cortexSialic AcidsNeural cell adhesion moleculeNeuroscienceCerebral Cortex
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