0000000000539136

AUTHOR

Achille Aouba

showing 3 related works from this author

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

2016

International audience; Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inflammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were…

Male0301 basic medicine[SHS.PSY]Humanities and Social Sciences/PsychologyKynurenic Acidchemistry.chemical_compound0302 clinical medicineKynurenic acidMast CellsIndoleamine 23-dioxygenaseAcute stressQuinolinic acidKynurenineDepression (differential diagnoses)DepressionTryptophanMiddle AgedMast cellRat-brain3. Good healthPsychiatry and Mental healthmedicine.anatomical_structure[ SCCO.NEUR ] Cognitive science/NeuroscienceFemalemedicine.symptomMastocytosisSerotoninmedicine.medical_specialtyInflammationAryl-hydrocarbon receptorCentral-nervous-system[ SHS.PSY ] Humanities and Social Sciences/Psychology03 medical and health sciencesCellular and Molecular NeuroscienceInternal medicinemedicineHumansIndoleamine-Pyrrole 23-Dioxygenase[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyMolecular BiologyInflammationPsychiatric Status Rating ScalesDepressive Disorder Majorbusiness.industry[SCCO.NEUR]Cognitive science/NeuroscienceBeck Depression InventoryInterferon-alphaMammalian brain030104 developmental biologyEndocrinologyImmune-systemchemistryImmunologyIndoleamine 2?3-dioxygenasebusinessStress Psychological030217 neurology & neurosurgeryKynurenineQuinolinic acid
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Systematic retrospective study of 64 patients with anti-Mi2 dermatomyositis: A classic skin rash with a necrotizing myositis and high risk of maligna…

2020

AdultMalemedicine.medical_specialtyRisk of malignancyMEDLINEDermatologyRisk AssessmentDermatomyositisNecrosisRisk FactorsNeoplasmsmedicineHumansMuscle SkeletalAgedAutoantibodiesRetrospective StudiesSkinbusiness.industryIncidenceNecrotizing myositisRetrospective cohort studyExanthemaMiddle AgedDermatomyositisPrognosismedicine.diseaseDermatologyRashFemalemedicine.symptombusinessMi-2 Nucleosome Remodeling and Deacetylase ComplexJournal of the American Academy of Dermatology
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Efficacy of Azacitidine (AZA) in Autoimmune and Inflammatory Disorders (AID) Associated with Myelodysplastic Syndromes (MDS) and Chronic Myelomonocyt…

2015

Abstract Background: AID are seen in 10-30% of MDS and CMML. After initial response to steroids, AID are often poorly controlled and steroid-sparing drugs are difficult to use due to the underlying MDS/CMML. Some case reports suggest a beneficial role of AZA treatment in AID associated to MDS/CMML. Methods: We retrospectively analyzed 22 MDS/CMML patients (pts) with AID who received AZA in French centers between January 2007 and May 2014. Results: Median age of the 22 pts was 70y (range 41-84), including 6F/16M. Diagnosis of MDS/CMML preceded AID (n=8) by a median of 17 months (mo), was concomitant with (n=7) or followed AID (n=7) by a median of 20 mo. 14 pts had lower risk IPSS and 8 highe…

[ SDV ] Life Sciences [q-bio]business.industryMyelodysplastic syndromes[SDV]Life Sciences [q-bio]ImmunologyAzacitidineChronic myelomonocytic leukemiaCell BiologyHematologymedicine.diseaseBiochemistryInappropriate sinus tachycardia3. Good healthSierra leonePolymyalgia rheumatica[SDV] Life Sciences [q-bio]Mineralocorticoid receptorImmunologymedicinebusinessRelapsing polychondritismedicine.drug
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