6533b820fe1ef96bd127a5da
RESEARCH PRODUCT
Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis
Sophie Georgin-lavialleDaniela Silva MouraAlexandre SalvadorJean-christophe Chauvet-gélinierJean-marie LaunayGhandi DamajF. CôtéErinn SouciéMarie-olivia ChandesrisStéphane BarèteCatherine Grandpeix-guyodoClaude BachmeyerMarie-alexandra AlyanakianAchille AoubaOlivier LortholaryPatrice DubreuilJean-raymond TeyssierBenoit TrojakEmmanuel HaffenPierre VandelBernard BoninOlivier HermineRaphaël GaillardOdile Beyne-rauzyChristian De GennesIsabelle DurieuO FainBernard GrosboisIsabelle GuichardMohamed HamidouDavid LaunayChristian LavigneChristina LivideanuFranck NicoliniR RetornazMichel ArockJean-benoit Arletsubject
Male0301 basic medicine[SHS.PSY]Humanities and Social Sciences/PsychologyKynurenic Acidchemistry.chemical_compound0302 clinical medicineKynurenic acidMast CellsIndoleamine 23-dioxygenaseAcute stressQuinolinic acidKynurenineDepression (differential diagnoses)DepressionTryptophanMiddle AgedMast cellRat-brain3. Good healthPsychiatry and Mental healthmedicine.anatomical_structure[ SCCO.NEUR ] Cognitive science/NeuroscienceFemalemedicine.symptomMastocytosisSerotoninmedicine.medical_specialtyInflammationAryl-hydrocarbon receptorCentral-nervous-system[ SHS.PSY ] Humanities and Social Sciences/Psychology03 medical and health sciencesCellular and Molecular NeuroscienceInternal medicinemedicineHumansIndoleamine-Pyrrole 23-Dioxygenase[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyMolecular BiologyInflammationPsychiatric Status Rating ScalesDepressive Disorder Majorbusiness.industry[SCCO.NEUR]Cognitive science/NeuroscienceBeck Depression InventoryInterferon-alphaMammalian brain030104 developmental biologyEndocrinologyImmune-systemchemistryImmunologyIndoleamine 2?3-dioxygenasebusinessStress Psychological030217 neurology & neurosurgeryKynurenineQuinolinic aciddescription
International audience; Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inflammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were enrolled in the study and compared healthy age-matched controls. Depression and stress were evaluated with the Beck Depression Inventory revised and the Perceived Stress Scale. All patients had measurements of TRP, serotonin (5-HT), kynurenine (KYN), indoleamine 2,3-dioxygenase 1 (IDO1) activity (ratio KYN/TRP), kynurenic acid (KA) and quinolinic acid (QA). Patients displayed significantly lower levels of TRP and 5-HT without hypoalbuminemia or malabsorption, higher IDO1 activity, and higher levels of KA and QA, with an imbalance towards the latter. High perceived stress and high depression scores were associated with low TRP and high IDO1 activity. In conclusion, TRP metabolism is altered in mastocytosis and correlates with perceived stress and depression, demonstrating mast cells' involvement in inflammation pathways linked to depression.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-11-01 |