0000000000476461

AUTHOR

David Launay

showing 2 related works from this author

Mast cells' involvement in inflammation pathways linked to depression: evidence in mastocytosis

2016

International audience; Converging sources of evidence point to a role for inflammation in the development of depression, fatigue and cognitive dysfunction. More precisely, the tryptophan (TRP) catabolism is thought to play a major role in inflammation-induced depression. Mastocytosis is a rare disease in which chronic symptoms, including depression, are related to mast cell accumulation and activation. Our objectives were to study the correlations between neuropsychiatric features and the TRP catabolism pathway in mastocytosis in order to demonstrate mast cells' potential involvement in inflammation-induced depression. Fifty-four patients with mastocytosis and a mean age of 50.1 years were…

Male0301 basic medicine[SHS.PSY]Humanities and Social Sciences/PsychologyKynurenic Acidchemistry.chemical_compound0302 clinical medicineKynurenic acidMast CellsIndoleamine 23-dioxygenaseAcute stressQuinolinic acidKynurenineDepression (differential diagnoses)DepressionTryptophanMiddle AgedMast cellRat-brain3. Good healthPsychiatry and Mental healthmedicine.anatomical_structure[ SCCO.NEUR ] Cognitive science/NeuroscienceFemalemedicine.symptomMastocytosisSerotoninmedicine.medical_specialtyInflammationAryl-hydrocarbon receptorCentral-nervous-system[ SHS.PSY ] Humanities and Social Sciences/Psychology03 medical and health sciencesCellular and Molecular NeuroscienceInternal medicinemedicineHumansIndoleamine-Pyrrole 23-Dioxygenase[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular BiologyMolecular BiologyInflammationPsychiatric Status Rating ScalesDepressive Disorder Majorbusiness.industry[SCCO.NEUR]Cognitive science/NeuroscienceBeck Depression InventoryInterferon-alphaMammalian brain030104 developmental biologyEndocrinologyImmune-systemchemistryImmunologyIndoleamine 2?3-dioxygenasebusinessStress Psychological030217 neurology & neurosurgeryKynurenineQuinolinic acid
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A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study.

2015

Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The…

AdultMalemedicine.medical_specialtyPathologyAdolescentKlinikai orvostudományokBiochemistryJuvenile systemic sclerosiSclerodermaMicroscopic AngioscopySystemic sclerosiScleroderma LocalizedYoung AdultMedicineJuvenileHumansYoung adultAge of Onsetskin and connective tissue diseasesChildNailfold CapillaroscopyVideocapillaroscopyAgedRetrospective StudiesEUSTARScleroderma Systemicintegumentary systemCapillaroscopybusiness.industrySimilar distributionMicrocirculationAutoantibodyRetrospective cohort studyOrvostudományokCell BiologyMiddle Agedmedicine.diseaseDermatologyCapillariesNailfold capillaroscopyFemaleAge of onsetCardiology and Cardiovascular MedicinebusinessCapillaroscopy; EUSTAR; Juvenile systemic sclerosis; Microcirculation; Nailfold capillaroscopy; Systemic sclerosis; Videocapillaroscopy; Biochemistry; Cardiology and Cardiovascular Medicine; Cell BiologyMicrovascular research
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