6533b870fe1ef96bd12d06c9
RESEARCH PRODUCT
A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study.
F. LaufferKati OtsaOliver DistlerS. ZeniMarco Matucci CerinicMaria Rosa PozziMargarita PileckyteJohn HightonPaola CaramaschiJacek SzechińskiMaria João SalvadorDiana KarpecMaurizio CutoloCodrina AncutaPatrizia BoracchiSimonetta PisarriFabiana MontoyaVanessa SmithMengtao LiCarolina De Souza MüllerPatricia CarreiraC. MihaiHenrik NielsenLuc MouthonL. DenisovMarc FrerixPier Luigi MeroniØYvind MidtvedtFrancesco Paolo CantatoreAda CorradoSebastião Cezar RadominskiSerena GuiducciFrancesco PuppoSimon StebbingsArmando GabrielliGiovanna CuomoIrena ButrimienePiotr WilandIra LitinskyMaria UprusMerete EngelhartRoger HesselstrandUlrich A WalkerRodica ChirieacUlf Müller-ladnerDavid LaunayKirsten DamgaardKamal SolankiCristina Mihaela TanaseanuTorhild GarenIsabela TigleaAleksandra StankovićL. AnanievaFrancesca IngegnoliMagdalena Szmyrka-kaczmarekJörg HenesAlan TyndallRoberta GualtierottiRüdiger HeinEwa MorgielEdoardo RosatoIvan FoeldvariValderílio Feijó AzevedoGitte StraussValeria RiccieriAnna KotulskaMarta Valero ExpositoR. BecvarJosé António Pereira Da SilvaBlaz RozmanVera Ortiz-santamariaPaloma García De La Peña LefebvreSzilvia SzamosiMałgorzata WiduchowskaGabriella SzücsMartin AringerPaulius VenalisRoberto CaporaliKilian EyerichFlorenzo IannoneAlina DumitrascuEugene J. KucharzLaura GroseanuAlessandra VaccaMonica PopescuCristiane KayserYannick AllanoreBrigitte Krummel-lorenzP. SaarMihai BojincaMagdalena Kopec-medrekEduardo KerzbergCecília VarjúNemanja DamjanovLuis Eduardo Coelho AndradeRita RugienePaolo AiròFilip De KeyserNicola UghiBojana StamenkovicClaudia GüntherRuxandra IonescuLászló CzirjákMatthias SeidelSilvia Rodriguez RubioPaola GottschalkDirk M. WuttgeAlan DoubeVanesa CosentinoThierry ZenoneDominique Farge-bancelEsthela LoyoAlgirdas VenalisRenata SokolikAlberto SulliRosario FotiStefan HeitmannEric HachullaJuan José Alegre-sanchoCarlomaurizio MontecuccoDaniela Oprissubject
AdultMalemedicine.medical_specialtyPathologyAdolescentKlinikai orvostudományokBiochemistryJuvenile systemic sclerosiSclerodermaMicroscopic AngioscopySystemic sclerosiScleroderma LocalizedYoung AdultMedicineJuvenileHumansYoung adultAge of Onsetskin and connective tissue diseasesChildNailfold CapillaroscopyVideocapillaroscopyAgedRetrospective StudiesEUSTARScleroderma Systemicintegumentary systemCapillaroscopybusiness.industrySimilar distributionMicrocirculationAutoantibodyRetrospective cohort studyOrvostudományokCell BiologyMiddle Agedmedicine.diseaseDermatologyCapillariesNailfold capillaroscopyFemaleAge of onsetCardiology and Cardiovascular MedicinebusinessCapillaroscopy; EUSTAR; Juvenile systemic sclerosis; Microcirculation; Nailfold capillaroscopy; Systemic sclerosis; Videocapillaroscopy; Biochemistry; Cardiology and Cardiovascular Medicine; Cell Biologydescription
Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% Cl 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% Cl 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of sderoderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue. (C) 2015 Elsevier Inc. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 | Microvascular research |