PLLA Scaffold with Gradient pore size in microphysiological tissue system bioreactor for Osteochondral regeneration

Cartilage and bone tissues in the joints are intimately linked and form the osteochondral unit. A better understanding of both disease and regenerative processes of bone and cartilage requires the study of both tissues together, as part of the osteochondral unit to account for their mutual interactions. However, the production of scaffolds for osteochondral tissue regeneration is a challenging task, since scaffolds must mimic the differents morphologies of cartilage and bone. Thermally Induced Phase Separation (TIPS) is one of the most adaptable techniques to produce porous scaffold for Tissue Engineering applications. A wide range of morphologies in terms of both pore size and distribution…

Modeling and experimental approaches for the characterization of phase equilibria in polymer solutions

Anisotropic scaffold for Bone Tissue Engineering

Theoretical Predictions and experimental determination of cloud point curves for polymeric solutions: an application to the ternary system Poly-lactic-acid (PLLA)-dioxane-water

The lattice fluid model with specific interactions was applied to the ternary system Poly-L-lactic-acid (PLLA)-dioxane-water. Model parameters were determined by fitting experimental data. The as-obtained parameters were used to calculate the complete phase diagram. An experimental apparatus for cloud point measurements, which is under construction, is presented.

A survey on models for the prediction of phase equilibria in polymer solutions

Membrane porose in PLLA per la rigenerazione di mucosa bronchiale umana ottenute mediante DIPS

An Innovative Method to Produce Scaffolds with a Pore Size Gradient for Tissue Engineering Applications

Thermally Induced Phase Separation (TIPS) is a technique for the production of porous scaffold for Tissue Engineering applications. A wide range of microporous morphologies, in terms of pore size and distribution, can be obtained by tuning TIPS processing parameters, especially thermal history. The production of scaffolds for bone tissue regeneration is a challenging target: as a matter of fact, scaffolds must mimic the bone morphology, thus requiring a gradient of pore dimension and morphology along one dimension. To attain this goal, an experimental apparatus capable to impose different thermal histories on the two sides of a sample was designed, set up and tested. The sample (35x35 mm su…

The concept and the application of no-flow temperature (NFT) in simulation of injection moulding

AN EXPERIMENTAL APPARATUS TO CHARACTERIZE PHASE SEPARATION IN POLYMER SOLUTIONS

CLOUD POINT MEASUREMENTS IN MEMBRANE FORMING SYSTEMS

Il concetto di "no-flow temperature" e il problema della solidificazione in flusso durante lo stadio di riempimento nel processo di stampaggio ad iniezione

Durante la fase di riempimento del processo di stampaggio ad iniezione, il flusso del materiale polimerico può fermarsi a causa della sua elevata viscosità, nonostante non sia avvenuta la solidificazione tramite transizione vetrosa o cristallizzazione. La no-flow temperature (NFT) è un parametro che rappresenta la "temperatura di solidificazione reologica" di un polimero, ed è utilizzata in molti software di simulazione del processo di stampaggio ad iniezione. L'estrapolazione della viscosità a basse temperature tramite modelli reologici può introdurre errori considerevoli nelle simulazioni, poichè le misure di viscosità sono usualmente effettuate ad alte temperature: in tal modo, i modelli…

Scaffolds biodegradabili in PLLA con gradiente di porosità per rigenerazione ossea

POLYMERIC POROUS STRUCTURES VIA PHASE SEPARATION

Temperature influence on the morphology of porous structures prepared via Thermally Induced Phase Separation (TIPS)

Peltier cells as temperature control elements: Experimental characterization and modelling

Characterization of commercial polymeric membranes for membrane distillation processes

An Innovative Method to Produce Scaffolds with a Pore Size Gradient for Tissue Engineering

Measurement of cloud point temperature in polymer solutions

Hydrophobic polymeric membranes: experimental characterization for membrane distillation applications

Solidification during the filling stage of injection molding: a simulation-oriented study

Membrane biodegradabili in PLLA preparate mediante DIPS (Diffusion Induced Phase Separation) come supporto per la rigenerazione di mucosa bronchiale umana

Membrane Distillation for a solar powered desalination pilot unit

A study via simulation of solidification during injection molding

The final properties of an injection-molded part are strictly dependent on the solidification dynamics occurring during the processing. The experimental derivation of information about polymer solidification throughout the injection molding cycle is still an open challenge. To overcome the practical issues, the process simulation is proposed as a mean to derive useful data, and especially for identifying the most influencing parameters. The no-flow temperature (NFT) is a parameter used in most of injection molding simulation packages as a mean to determine whether the polymer flows or it is solid. With this simple parameter it is possible to take into account the rheological solidification …