0000000000541945

AUTHOR

Hans-gerd Lennartz

showing 3 related works from this author

NMR-Spektroskopie an Heterocyclen, 6. Mitt. Favorskii-Umlagerung von α-Brom-β-methoxy-ketonen bei der Imidazol-Cyclisierung in flüssigem Ammoniak

1979

Bei der Imidazolsynthese aus α-Bromketonen und Formiminoethylester in flussigem Ammoniak werden α-alkylsubstituierte Buttersaure-Amide als Nebenprodukte erhalten, deren Entstehen einer Favorskii-Umlagerung zugeschrieben wird. Die isolierten Verbindungen wurden NMR-spektroskopisch untersucht. NMR Spectroscopy of Heterocycles. VI: Favorskii Rearrangement of α-Bromo-β-methoxy Ketones During Imidazole Cyclisation in Liquid Ammonia. During imidazole synthesis with α-bromo ketones and formiminic ethyl ester in liquid ammonia α-alkylbutyric amides were obtained as by-products. Their formation is attributed to a Favorskii rearrangement. The compounds were investigated by NMR spectroscopy.

chemistry.chemical_compoundChemistryDrug DiscoveryPolymer chemistryLiquid ammoniaPharmaceutical ScienceImidazoleNuclear magnetic resonance spectroscopyEthyl esterFavorskii rearrangementArchiv der Pharmazie
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Struktur-Wirkungs-Beziehungen bei Histaminanaloga, 13. Mitt.: 5(4)-Cyclisch substituierte Histamine und Nα-Methyl-histamine

1976

Es wird die Darstellung von 5(4)-cyclisch substituierten Histaminen und Nα-Methyl-histaminen durch Cyclisierung von 1-aryl-substituierten 2-Brom-4-phthalimido-butan-1-onen mit Formamid oder Benzamidin und anschliesende Hydrolyse bzw. Reduktion der Zwischenprodukte beschrieben. C-5(4) Cyclic Substituted Histamines and Nα-Methylhistamines The preparation of C-5(4) cyclic substituted histamines and Nα-methylhistamines by cyclisation of 1-aryl-2-bromo-4-phthalimidobutan-1-ones with formamide or benzamidine, followed by hydrolysis or reduction of the intermediates, is described.

Formamidechemistry.chemical_compoundHydrolysisChemistryDrug DiscoveryPharmaceutical ScienceOxidation reductionMedicinal chemistryHistamineBenzamidineArchiv der Pharmazie
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Structure-activity relationship of histamine H2-receptor agonists

1978

As demonstrated by the results the active C-5(4) substituted histamines and Nα-methyl-histamines are to various extents selective H2-receptor agonists.

PharmacologyAllergybusiness.industryImmunologyPharmacology toxicologyPharmacologyToxicologymedicine.diseasechemistry.chemical_compoundchemistryHistamine H2 receptormedicineStructure–activity relationshipPharmacology (medical)ReceptorbusinessHistamineAgents and Actions
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