0000000000543057

AUTHOR

Ildebrando D’angelo

showing 5 related works from this author

On Unsupervised Methods for Medical Image Segmentation: Investigating Classic Approaches in Breast Cancer DCE-MRI

2021

Unsupervised segmentation techniques, which do not require labeled data for training and can be more easily integrated into the clinical routine, represent a valid solution especially from a clinical feasibility perspective. Indeed, large-scale annotated datasets are not always available, undermining their immediate implementation and use in the clinic. Breast cancer is the most common cause of cancer death in women worldwide. In this study, breast lesion delineation in Dynamic Contrast Enhanced MRI (DCE-MRI) series was addressed by means of four popular unsupervised segmentation approaches: Split-and-Merge combined with Region Growing (SMRG), k-means, Fuzzy C-Means (FCM), and spatial FCM (…

Fluid Flow and Transfer ProcessesTechnologymedical image segmentationQH301-705.5Process Chemistry and TechnologyTPhysicsQC1-999pattern recognitionGeneral EngineeringEngineering (General). Civil engineering (General)Breast cancer; Clinical feasibility; Computer-assisted segmentation; Machine learning; Magnetic resonance imaging; Medical image segmentation; Pattern recognitionComputer Science ApplicationsChemistrybreast cancermachine learningclinical feasibilitymagnetic resonance imagingGeneral Materials Sciencemedical image segmentation; breast cancer; pattern recognition; machine learning; clinical feasibility; magnetic resonance imaging; computer-assisted segmentationTA1-2040Biology (General)InstrumentationQD1-999computer-assisted segmentation
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Semi-automated and interactive segmentation of contrast-enhancing masses on breast DCE-MRI using spatial fuzzy clustering

2022

Abstract Multiparametric Magnetic Resonance Imaging (MRI) is the most sensitive imaging modality for breast cancer detection and is increasingly playing a key role in lesion characterization. In this context, accurate and reliable quantification of the shape and extent of breast cancer is crucial in clinical research environments. Since conventional lesion delineation procedures are still mostly manual, automated segmentation approaches can improve this time-consuming and operator-dependent task by annotating the regions of interest in a reproducible manner. In this work, a semi-automated and interactive approach based on the spatial Fuzzy C-Means (sFCM) algorithm is proposed, used to segme…

Fuzzy clusteringUnsupervised fuzzy clusteringbusiness.industryComputer scienceBiomedical EngineeringHealth InformaticsPattern recognitionImage processingContext (language use)Image segmentationComputer-assisted lesion detectionMagnetic Resonance ImagingThresholdingConvolutional neural networkBreast cancer; Computer-assisted lesion detection; Magnetic Resonance Imaging; Semi-automated segmentation; Spatial information; Unsupervised fuzzy clusteringBreast cancerSignal ProcessingSemi-automated segmentationSpatial informationSegmentationArtificial intelligencebusinessMultiparametric Magnetic Resonance ImagingBiomedical Signal Processing and Control
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Robustness Analysis of DCE-MRI-Derived Radiomic Features in Breast Masses: Assessing Quantization Levels and Segmentation Agreement

2022

Featured Application The use of highly robust radiomic features is fundamental to reduce intrinsic dependencies and to provide reliable predictive models. This work presents a study on breast tumor DCE-MRI considering the radiomic feature robustness against the quantization settings and segmentation methods. Machine learning models based on radiomic features allow us to obtain biomarkers that are capable of modeling the disease and that are able to support the clinical routine. Recent studies have shown that it is fundamental that the computed features are robust and reproducible. Although several initiatives to standardize the definition and extraction process of biomarkers are ongoing, th…

Fluid Flow and Transfer Processesradiomic featuresrobustness analysis; radiomic features; quantization levels; segmentation method agreement; DCE-MRI; breast tumorsbreast tumorDCE-MRIProcess Chemistry and TechnologyGeneral Engineeringbreast tumors; DCE-MRI; quantization levels; radiomic features; robustness analysis; segmentation method agreementComputer Science Applicationsquantization levelsrobustness analysisGeneral Materials Sciencesegmentation method agreementbreast tumorsInstrumentation
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3D DCE-MRI Radiomic Analysis for Malignant Lesion Prediction in Breast Cancer Patients

2022

Rationale and Objectives: To develop and validate a radiomic model, with radiomic features extracted from breast Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) from a 1.5T scanner, for predicting the malignancy of masses with enhancement. Images were acquired using an 8-channel breast coil in the axial plane. The rationale behind this study is to show the feasibility of a radio-mics-powered model that could be integrated into the clinical practice by exploiting only standard-of-care DCE-MRI with the goal of reducing the required image pre-processing (ie, normalization and quantitative imaging map generation).Materials and Methods: 107 radiomic features were extracted from a …

Breast cancer Dynamic contrast-enhanced magnetic resonance imagingSupport Vector MachineComputer scienceNormalization (image processing)Breast NeoplasmsFeature selectionBreast cancerBreast cancerDiscriminative modelmedicineHumansRadiology Nuclear Medicine and imagingBreastRetrospective StudiesDynamic contrast-enhanced magnetic resonance imagingRadiomicsSupport vector machinesReceiver operating characteristicbusiness.industryPattern recognitionmedicine.diseaseMagnetic Resonance Imagingmachine learning Radiomics unsupervised feature selection Support vector machinesSupport vector machinemachine learningROC CurveFeature (computer vision)Test setFemaleArtificial intelligenceSettore MED/36 - Diagnostica Per Immagini E Radioterapiabusinessunsupervised feature selectionBreast cancer Dynamic contrast-enhanced magnetic resonance imaging; machine learning Radiomics unsupervised feature selection Support vector machinesAcademic Radiology
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Stereotactic Radiotherapy in Early-Stage Breast Cancer in Neoadjuvant and Exclusive Settings: A Systematic Review

2022

<b><i>Introduction:</i></b> Breast cancer (BC) is one of the most common tumors; better screening policies and multidisciplinary approach allow personalized treatment. Radiotherapy (RT) plays a central role in the multimodal approach in BC, and recent evidence has shown the non-inferiority of hypofractionated treatments. The aim of this study was to describe the feasibility and validity of stereotactic RT (SBRT) in BC in a neoadjuvant and exclusive setting. <b><i>Methods:</i></b> A PubMed/MEDLINE and Embase systematic review was conducted to assess the role of radiomics in BC. The search strategy was “breast [All Fields] AND “stereotactic” [Al…

Cancer ResearchBreast cancerSBRTOncologyRadiotherapySettore MED/06 - Oncologia MedicaHematology
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