0000000000543765

AUTHOR

Sophie Slack

showing 3 related works from this author

Regio- and Stereoselective Synthesis of 3-Pyrazolylidene-2-oxindole Compounds by Nucleophilic Vinylic Substitution of (E)-3-(Nitromethylene)indolin-2…

2019

[EN] A highly regio- and stereoselective synthesis of 3-alkylidene-2-oxindoles has been described through a nucleophilic vinylic substitution (SNV) of (E)-3-(nitromethylene)indolin-2-one using pyrazol-3-ones as nucleophiles and Et3N as a base. The reaction affords selectively the Z-isomer when pyrazol-3-ones without substituents at the 4 position are used. While the reaction is E-selective with 4- substituted pyrazolones. The stereoselectivity (up to >20:1) and the yields (up to 98%) are very high under mild reaction conditions.

010405 organic chemistryChemistryStereochemistryEstereoquímica2-oxindoleSubstitution (logic)2-oxindoleStereoselectivityGeneral ChemistryIndolin 2 one010402 general chemistry01 natural sciences0104 chemical sciencesReaccions químiquesRegioselectivityNucleophileFISICA APLICADAmedia_common.cataloged_instancePyrazoloneStereoselectivityEuropean unionmedia_commonVinylic substitution
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CCDC 1889981: Experimental Crystal Structure Determination

2019

Related Article: Carlos Vila, Sophie Slack, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2019|Adv.Synth.Catal.|361|1902|doi:10.1002/adsc.201900048

Space GroupCrystallography1-benzyl-3-[(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylidene]-57-dimethyl-13-dihydro-2H-indol-2-oneCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1890014: Experimental Crystal Structure Determination

2019

Related Article: Carlos Vila, Sophie Slack, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro|2019|Adv.Synth.Catal.|361|1902|doi:10.1002/adsc.201900048

Space GroupCrystallographyCrystal SystemCrystal Structure1-benzyl-3-[(34-dimethyl-5-oxo-1-phenyl-45-dihydro-1H-pyrazol-4-yl)methylidene]-13-dihydro-2H-indol-2-oneCell ParametersExperimental 3D Coordinates
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