0000000000544371
AUTHOR
Samuel Asensio
What Is the “Trigger” of Addiction?
Este artículo se encuentra disponible en la siguiente URL: https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00054/full
Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment
Background: Most of the previously published data suggest a role for oxidative or nitrosative stress in ethanol-induced nervous system damage. Moreover, ethanol is able to impair learning abilities in adult mammalian brain, a process suggested to be directly related to hippocampal neurogenesis. Ebselen, a synthetic compound with antioxidant properties, is able to prevent ethanol-induced impairment of neurogenesis in adult rats. The aim of the present work was to further demonstrate the ability of ebselen to prevent biochemical alterations, and preserve long-term potentiation (LTP) and learning abilities, in the hippocampus of chronic alcoholic adult rats. Methods: Biochemical markers of oxi…